Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 61219

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HXB2 Location	Gag(180-188) p24(48-56) DNA(1327..1353)	Gag Epitope Map
Author Location	p24
Epitope	TPYDINQML	Epitope Alignment
Epitope Name	TL9
Species (MHC/HLA)	human
Immunogen	HIV-2 infection
Patient MHC/HLA	012-006: A*03, A*23, B*35, B*53, C*04; 012-088: A*02, B*27, B*53, C*02, C*04; 019-010: A*33, A*68, B*53, C*04; 023-008: A*34, B*07, B*53, C*04, C*07; 036-018: A*03, B*35, B*53, C*04; 045-007: A*33, B*53, C*04; 082-005: A*23, A*34, B*53, C*04
Country	France
Experimental methods	CTL suppression of replication, Intracellular cytokine staining
Keywords	HIV-2

Notes

• CTL lymphopoietic potential and virus suppressive capacity were studied in 20 cART-naive, HIV-2-positive subjects with controlled viremia (HIC2). Production of HIV-2 Gag-specific CTL with (1) early memory differentiation as well as (2) robust effector potential was preserved in HIC2.
• 7/20 subjects were B*5301-positive and all recognized immunodominant Gag p24 epitope TPYDINQML (TL9).

References

Angin2016 Mathieu Angin, Glenn Wong, Laura Papagno, Pierre Versmisse, Annie David, Charles Bayard, Bénédicte Charmeteau-De Muylder, Amel Besseghir, Rodolphe Thiébaut, Faroudy Boufassa, Gianfranco Pancino, Delphine Sauce, Olivier Lambotte, Françoise Brun-Vézinet, Sophie Matheron, Sarah L. Rowland-Jones, Rémi Cheynier, Asier Sáez-Cirión, Victor Appay, and ANRS CO5 IMMUNOVIR-2 Study Group. Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers. J. Immunol., 197(7):2787-2795, 1 Oct 2016. PubMed ID: 27566819. Show all entries for this paper.

Displaying record number 61221

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HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	p24
Epitope	KRWIILGLNK	Epitope Alignment
Epitope Name	KK10
Species (MHC/HLA)	human(B*27:05)
Immunogen	HIV-2 infection
Country	France
Experimental methods	CTL suppression of replication, Intracellular cytokine staining
Keywords	HIV-2

Notes

• CTL lymphopoietic potential and virus suppressive capacity were studied in 20 cART-naive, HIV-2-positive subjects with controlled viremia (HIC2). Production of HIV-2 Gag-specific CTL with (1) early memory differentiation as well as (2) robust effector potential was preserved in HIC2.
• B*2705-restricted HIV-1 epitope KK10, KRWIILGLNK, was used as a control prototype for recognition by primary effector CTL and compared to the HIV-2 epitope-specific CTL in this study.

References

Angin2016 Mathieu Angin, Glenn Wong, Laura Papagno, Pierre Versmisse, Annie David, Charles Bayard, Bénédicte Charmeteau-De Muylder, Amel Besseghir, Rodolphe Thiébaut, Faroudy Boufassa, Gianfranco Pancino, Delphine Sauce, Olivier Lambotte, Françoise Brun-Vézinet, Sophie Matheron, Sarah L. Rowland-Jones, Rémi Cheynier, Asier Sáez-Cirión, Victor Appay, and ANRS CO5 IMMUNOVIR-2 Study Group. Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers. J. Immunol., 197(7):2787-2795, 1 Oct 2016. PubMed ID: 27566819. Show all entries for this paper.

Displaying record number 61220

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HXB2 Location	Gag(298-306) p24(166-174) DNA(1681..1707)	Gag Epitope Map
Author Location	p24
Epitope	DRFYKSLRA	Epitope Alignment
Epitope Name	DA9
Species (MHC/HLA)	human
Immunogen	HIV-2 infection
Patient MHC/HLA	012-009: A*03, A*74, B*14, B*15, C*07, C*08; 036-019: A*23, B*07, B*14, C*07, C*08
Country	France
Experimental methods	CTL suppression of replication, Intracellular cytokine staining
Keywords	HIV-2

Notes

• CTL lymphopoietic potential and virus suppressive capacity were studied in 20 cART-naive, HIV-2-positive subjects with controlled viremia (HIC2). Production of HIV-2 Gag-specific CTL with (1) early memory differentiation as well as (2) robust effector potential was preserved in HIC2.
• 2/20 subjects were B*1401-positive and all recognized Gag p24 epitope DRFYKSLRA (DA9).

References

Angin2016 Mathieu Angin, Glenn Wong, Laura Papagno, Pierre Versmisse, Annie David, Charles Bayard, Bénédicte Charmeteau-De Muylder, Amel Besseghir, Rodolphe Thiébaut, Faroudy Boufassa, Gianfranco Pancino, Delphine Sauce, Olivier Lambotte, Françoise Brun-Vézinet, Sophie Matheron, Sarah L. Rowland-Jones, Rémi Cheynier, Asier Sáez-Cirión, Victor Appay, and ANRS CO5 IMMUNOVIR-2 Study Group. Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers. J. Immunol., 197(7):2787-2795, 1 Oct 2016. PubMed ID: 27566819. Show all entries for this paper.