Search CTL/CD8+ T-Cell Epitope Database

Found 13 matching records:

Displaying record number 1314

HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	p17
Epitope	SLYNTVATL	Epitope Alignment
Epitope Name	p17 SL9
Species (MHC/HLA)	human(A*0201)
Immunogen	HIV-1 infection
Experimental methods
Keywords	supertype, computational epitope prediction

Notes

• HIV was scanned for all peptides which carried the A2-supermotif pattern conserved in more than 50% of B clade sequences -- 233 peptides met this criteria, and 30 of these bound to HLA-A*0201 -- 20/30 bound to at least 3/5 of HLA-A2 supertype alleles tested.
• Three additional previously described HLA-A2 epitopes were added to the set of 20, including p17 SL9, and 18/22 chronically infected HLA-A2 individuals had CTL that recognized at least one of the 23 peptides (median of 2 and maximum of 6), while 6/12 acute infected individuals recognized at least 1 (median of 1 and maximum of 2).
• p17 SL9 was recognized in 12/22 patients with chronic HIV-1 infection.
• Only 1/13 patients with acute HIV-1 infection recognized p17 SL9.

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.

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Displaying record number 1305

HXB2 Location	Gag(362-370) p24(230)-p2p7p1p6(7) DNA(1873..1899)	Gag Epitope Map
Author Location	Gag(386-)
Epitope	VLAEAMSQV	Epitope Alignment
Epitope Name	Gag-386
Species (MHC/HLA)	human(A*0201)
Immunogen	HIV-1 infection
Experimental methods
Keywords	binding affinity, supertype, computational epitope prediction, immunodominance, HLA cross-presentation

Notes

• HIV was scanned for all peptides which carried the A2-supermotif pattern conserved in more than 50% of B clade sequences -- 233 peptides met this criteria, and 30 of these bound to HLA-A*0201 -- 20/30 bound to at least 3/5 of HLA-A2 supertype alleles tested.
• Three additional previously described HLA-A2 epitopes were added to the set of 20, and 18/22 chronically infected HLA-A2 individuals had CTL that recognized at least one of the 23 peptides (median of 2 and maximum of 6), while 6/12 acute infected individuals recognized at least 1 (median of 1 and maximum of 2)
• VLAEAMSQV binds to all five HLA-A2 supertype alleles tested: A*0201, A*0202, A*0203, A*0206 and A*6802 (highest affinity)
• 4/22 individuals with chronic HIV-1 infection recognized this epitope, and it was immunodominant in 3/4 by ELISPOT.
• 0/12 acutely infected individuals recognized this epitope.

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.

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Displaying record number 1306

HXB2 Location	Pol(132-140) Protease(76-84) DNA(2478..2504)	Pol Epitope Map
Author Location	Pol(163-)
Epitope	LVGPTPVNI	Epitope Alignment
Epitope Name	Pol-163
Species (MHC/HLA)	human(A*0201)
Immunogen	HIV-1 infection
Experimental methods
Keywords	binding affinity, supertype, computational epitope prediction, HLA cross-presentation

Notes

• HIV was scanned for all peptides which carried the A2-supermotif pattern conserved in more than 50% of B clade sequences -- 233 peptides met this criteria, and 30 of these bound to HLA-A*0201 -- 20/30 bound to at least 3/5 of HLA-A2 supertype alleles tested.
• Three additional previously described HLA-A2 epitopes were added to the set of 20, and 18/22 chronically infected HLA-A2 individuals had CTL that recognized at least one of the 23 peptides (median of 2 and maximum of 6), while 6/12 acute infected individuals recognized at least 1 (median of 1 and maximum of 2)
• LVGPTPVNI binds to 4/5 HLA-A2 supertype alleles: A*0201, A*0202, A*0206 (highest affinity) and A*6802, but not A*0203.
• 1/22 individuals with chronic HIV-1 infection recognized this epitope by ELISPOT.
• 0/12 acutely infected individuals recognized this epitope.

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.

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Displaying record number 1307

HXB2 Location	Pol(282-290) RT(127-135) DNA(2928..2954)	Pol Epitope Map
Author Location	Pol(316-)
Epitope	YTAFTIPSI	Epitope Alignment
Epitope Name	Pol-316
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	binding affinity, supertype, computational epitope prediction, HLA cross-presentation

Notes

• HIV was scanned for all peptides which carried the A2-supermotif pattern conserved in more than 50% of B clade sequences -- 233 peptides met this criteria, and 30 of these bound to HLA-A*0201 -- 20/30 bound to at least 3/5 of HLA-A2 supertype alleles tested.
• Three additional previously described HLA-A2 epitopes were added to the set of 20, and 18/22 chronically infected HLA-A2 individuals had CTL that recognized at least one of the 23 peptides (median of 2 and maximum of 6), while 6/12 acute infected individuals recognized at least 1 (median of 1 and maximum of 2)
• 2/22 individuals with chronic HIV-1 infection recognized this epitope in ELISPOT.
• 0/12 acutely infected individuals recognized this epitope.
• YTAFTIPSI binds to five HLA-A2 supertype alleles: A*0201, A*0202,A*0203, A*0206 and A*6802 (highest affinity)

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.

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Displaying record number 1315

HXB2 Location	Pol(334-342) RT(179-187) DNA(3084..3110)	Pol Epitope Map
Author Location	RT
Epitope	VIYQYMDDL	Epitope Alignment
Epitope Name	RT VL9
Species (MHC/HLA)	human(A*0201)
Immunogen	HIV-1 infection
Experimental methods
Keywords	supertype, computational epitope prediction

Notes

• HIV was scanned for all peptides which carried the A2-supermotif pattern conserved in more than 50% of B clade sequences -- 233 peptides met this criteria, and 30 of these bound to HLA-A*0201 -- 20/30 bound to at least 3/5 of HLA-A2 supertype alleles tested.
• Three additional previously described HLA-A2 epitopes were added to the set of 20, including RT VL9, and 18/22 chronically infected HLA-A2 individuals had CTL that recognized at least one of the 23 peptides (median of 2 and maximum of 6), while 6/12 acute infected individuals recognized at least 1 (median of 1 and maximum of 2)
• RT VL9 was not recognized by any of the 22 HLA-A2 patients with chronic HIV-1 infection or the 13 HLA-A2 patients with acute HIV-1 infection included in this study.

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.

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Displaying record number 1313

HXB2 Location	Pol(464-472) RT(309-317) DNA(3474..3500)	Pol Epitope Map
Author Location	RT
Epitope	ILKEPVHGV	Epitope Alignment
Epitope Name	RT IV9
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	binding affinity, supertype, computational epitope prediction, HLA cross-presentation

Notes

• HIV was scanned for all peptides which carried the A2-supermotif pattern conserved in more than 50% of B clade sequences -- 233 peptides met this criteria, and 30 of these bound to HLA-A*0201 -- 20/30 bound to at least 3/5 of HLA-A2 supertype alleles tested.
• Three additional previously described HLA-A2 epitopes were added to the set of 20, and 18/22 chronically infected HLA-A2 individuals had CTL that recognized at least one of the 23 peptides (median of 2 and maximum of 6), while 6/12 acute infected individuals recognized at least 1 (median of 1 and maximum of 2)
• This peptide binds to four HLA-A2 supertype alleles: A*0201, A*0202, A*0206 (highest affinity) and A*6802.
• RT IV9 was recognized in 7/22 patients with chronic HIV-1 infection.
• 1/13 patients with acute HIV-1 infection recognized RT IV9.

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.

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Displaying record number 1190

HXB2 Location	Vpr(59-67) DNA(5733..5759)	Vpr Epitope Map
Author Location	Vpr(58-66 LAI)
Epitope	AIIRILQQL	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*0201)
Immunogen
Experimental methods
Keywords	optimal epitope

Notes

• C. Brander notes this is an A*0201 epitope.

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

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Displaying record number 1310

HXB2 Location	Vpr(59-67) DNA(5733..5759)	Vpr Epitope Map
Author Location	Vpr(59-)
Epitope	AIIRILQQL	Epitope Alignment
Epitope Name	Vpr-59
Species (MHC/HLA)	human(A*0201)
Immunogen	HIV-1 infection
Experimental methods
Keywords	binding affinity, supertype, computational epitope prediction, immunodominance, HLA cross-presentation

Notes

• HIV was scanned for all peptides which carried the A2-supermotif pattern conserved in more than 50% of B clade sequences -- 233 peptides met this criteria, and 30 of these bound to HLA-A*0201 -- 20/30 bound to at least 3/5 of HLA-A2 supertype alleles tested.
• Three additional previously described HLA-A2 epitopes were added to the set of 20, and 18/22 chronically infected HLA-A2 individuals had CTL that recognized at least one of the 23 peptides (median of 2 and maximum of 6), while 6/12 acute infected individuals recognized at least 1 (median of 1 and maximum of 2)
• AIIRILQQL binds to four HLA-A2 supertype alleles: A*0203, A*0201, A*0206 and A*6802 (highest affinity), but not A*0202.
• 5/22 individuals with chronic HIV-1 infection recognized this epitope, but with low magnitude responses in ELISPOT.
• 2/12 HLA-A2 patients with acute HIV-1 infection responded strongly to this peptide, but during chronic infection SL9 and Gag-386 tended to be immunodominant while Vpr-59 was weak and sub-dominant.
• One of the acutely infected individuals, AC13, was HLA A*0201/68 B44/14 and also had a strong acute response to gp41 epitope SV10 SLLNATDIAV.
• This peptide was shown to be properly processed and presented in TAP-competent B-cell lines in vitro.

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.

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Displaying record number 1311

HXB2 Location	Vpr(62-70) DNA(5742..5768)	Vpr Epitope Map
Author Location	Vpr(62-)
Epitope	RILQQLLFI	Epitope Alignment
Epitope Name	Vpr-62
Species (MHC/HLA)	human(A*0201)
Immunogen	HIV-1 infection
Experimental methods
Keywords	binding affinity, supertype, computational epitope prediction, HLA cross-presentation

Notes

• HIV was scanned for all peptides which carried the A2-supermotif pattern conserved in more than 50% of B clade sequences -- 233 peptides met this criteria, and 30 of these bound to HLA-A*0201 -- 20/30 bound to at least 3/5 of HLA-A2 supertype alleles tested.
• Three additional previously described HLA-A2 epitopes were added to the set of 20, and 18/22 chronically infected HLA-A2 individuals had CTL that recognized at least one of the 23 peptides (median of 2 and maximum of 6), while 6/12 acute infected individuals recognized at least 1 (median of 1 and maximum of 2)
• This epitope binds to three HLA-A2 supertype alleles: A*0202, A*6802 (strongest affinity) and A*0203.
• 3/22 chronically infected patients had a weak ELISPOT response to this epitope.
• 0/12 HLA-A2 patients with acute HIV-1 infection responded to this peptide.

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.

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Displaying record number 1308

HXB2 Location	gp160(121-129) gp120(121-129) DNA(6585..6611)	gp160 Epitope Map
Author Location	Env(134-)
Epitope	KLTPLCVTL	Epitope Alignment
Epitope Name	Env-134
Species (MHC/HLA)	human(A*0201)
Immunogen	HIV-1 infection
Experimental methods
Keywords	binding affinity, supertype, computational epitope prediction, HLA cross-presentation

Notes

• HIV was scanned for all peptides which carried the A2-supermotif pattern conserved in more than 50% of B clade sequences -- 233 peptides met this criteria, and 30 of these bound to HLA-A*0201 -- 20/30 bound to at least 3/5 of HLA-A2 supertype alleles tested.
• Three additional previously described HLA-A2 epitopes were added to the set of 20, and 18/22 chronically infected HLA-A2 individuals had CTL that recognized at least one of the 23 peptides (median of 2 and maximum of 6), while 6/12 acute infected individuals recognized at least 1 (median of 1 and maximum of 2)
• 2/22 individuals with chronic HIV-1 infection recognized this epitope in ELISPOT.
• 0/12 acutely infected individuals recognized this epitope.
• KLTPLCVTL binds to four HLA-A2 supertype alleles: A*0201, A*0202, A*0203 and A*6802 (highest affinity).

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.

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Displaying record number 1312

HXB2 Location	gp160(813-822) gp41(302-311) DNA(8661..8690)	gp160 Epitope Map
Author Location	gp41
Epitope	SLLNATDIAV	Epitope Alignment
Epitope Name	gp41 SV10
Species (MHC/HLA)	human(A68)
Immunogen	HIV-1 infection
Experimental methods
Keywords	binding affinity, supertype, computational epitope prediction, HLA cross-presentation

Notes

• HIV was scanned for all peptides which carried the A2-supermotif pattern conserved in more than 50% of B clade sequences -- 233 peptides met this criteria, and 30 of these bound to HLA-A*0201 -- 20/30 bound to at least 3/5 of HLA-A2 supertype alleles tested.
• Three additional previously described HLA-A2 epitopes were added to the set of 20, and 18/22 chronically infected HLA-A2 individuals had CTL that recognized at least one of the 23 peptides (median of 2 and maximum of 6), while 6/12 acute infected individuals recognized at least 1 (median of 1 and maximum of 2)
• This epitope binds to three HLA-A2 supertype alleles: A*6802 (highest affinity), A*0202 and A*0203 (but not A*0201 and not A*0206)
• This epitope did not elicit an ELISPOT response in 22 chronic HIV HLA-A2 infections, but elicited a strong response in 1/12 acute HLA-A2 infections -- this individual, AC13, was HLA A*0201/68 B44/14 and also had a strong response to HLA-A2 vpr epitope AIIRILQQL.

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.

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Displaying record number 1309

HXB2 Location	Nef(137-146) DNA(9205..9234)	Nef Epitope Map
Author Location	Nef( 221A)
Epitope	LTFGWCFKLV	Epitope Alignment
Epitope Name	Nef-221a
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	binding affinity, supertype, computational epitope prediction, HLA cross-presentation

Notes

• HIV was scanned for all peptides which carried the A2-supermotif pattern conserved in more than 50% of B clade sequences -- 233 peptides met this criteria, and 30 of these bound to HLA-A*0201 -- 20/30 bound to at least 3/5 of HLA-A2 supertype alleles tested.
• Three additional previously described HLA-A2 epitopes were added to the set of 20, and 18/22 chronically infected HLA-A2 individuals had CTL that recognized at least one of the 23 peptides (median of 2 and maximum of 6), while 6/12 acute infected individuals recognized at least 1 (median of 1 and maximum of 2)
• 1/22 individuals with chronic HIV-1 infection recognized this epitope in ELISPOT.
• 2/12 acutely infected individuals recognized this epitope.
• LTFGWCFKLV binds to five HLA-A2 supertype alleles: A*0203, A*0201 (highest affinity), A*0206, A*6802 and A*0202.

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.

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Displaying record number 1316

HXB2 Location	Nef(190-198) DNA(9364..9390)	Nef Epitope Map
Author Location	Nef
Epitope	AFHHVAREL	Epitope Alignment
Epitope Name	Nef AL9
Species (MHC/HLA)	human(A*0201)
Immunogen	HIV-1 infection
Experimental methods
Keywords	supertype, computational epitope prediction

Notes

• HIV was scanned for all peptides which carried the A2-supermotif pattern conserved in more than 50% of B clade sequences -- 233 peptides met this criteria, and 30 of these bound to HLA-A*0201 -- 20/30 bound to at least 3/5 of HLA-A2 supertype alleles tested.
• Three additional previously described HLA-A2 epitopes were added to the set of 20, including p17 SL9, and 18/22 chronically infected HLA-A2 individuals had CTL that recognized at least one of the 23 peptides (median of 2 and maximum of 6), while 6/12 acute infected individuals recognized at least 1 (median of 1 and maximum of 2).
• p17 SL9 was recognized in 12/22 patients with chronic HIV-1 infection.
• Only 1/13 patients with acute HIV-1 infection recognized p17 SL9.

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.

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