Search CTL/CD8+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 53201

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HXB2 Location	Gag(18-26) p17(18-26) DNA(841..867)	Gag Epitope Map
Author Location	p17(18-26 B consensus)
Epitope	KIRLRPGGK	Epitope Alignment
		Show epitope variants
Epitope Name	KK9
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	epitope processing, immunodominance, escape, acute/early infection, characterizing CD8+ T cells, viral fitness and reversion

Notes

• KK9 and RK9 overlap, are presented by HLA-A3, and are frequently immunodominant and involved in acute-phase primary responses. A mutation in the C-terminal flanking residue of KK9 (K to Q) (kirlrpkkg-Q) inhibits processing of the immunodominant gag KK9 epitope, resulting in rapid decline in the KK9 specific CD8+ T-cell response. At the same time it abrogates the response to RK9 through the embedded mutation rlrpggkQk. Transmission of this mutation to patients expressing HLA-A3 prevents acute-phase response to these epitopes, although the mutation can eventually revert to wild-type allowing a delayed response to the epitope.

References

Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.

Displaying record number 53202

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HXB2 Location	Gag(20-28) p17(20-28) DNA(847..873)	Gag Epitope Map
Author Location	p17(20-28 B consensus)
Epitope	RLRPGGKKK	Epitope Alignment
		Show epitope variants
Epitope Name	RK9
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	immunodominance, escape, acute/early infection, characterizing CD8+ T cells, viral fitness and reversion

Notes

• KK9 and RK9 overlap, are presented by HLA-A3, and are frequently immunodominant and involved in acute-phase primary responses. A mutation in the C-terminal flanking residue of KK9 (K to Q) (kirlrpkkg-Q) inhibits processing of the immunodominant gag KK9 epitope, resulting in rapid decline in the KK9 specific CD8+ T-cell response. At the same time it abrogates the response to RK9 through the embedded mutation rlrpggkQk. Transmission of this mutation to patients expressing HLA-A3 prevents acute-phase response to these epitopes, although the mutation can eventually revert to wild-type allowing a delayed response to the epitope.

References

Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.

Displaying record number 53206

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HXB2 Location	Gag(71-79) p17(71-79) DNA(1000..1026)	Gag Epitope Map
Author Location	(71-79 B consensus)
Epitope	GSEELRSLY	Epitope Alignment
Epitope Name	GY9
Subtype	B
Species (MHC/HLA)	human(A1)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	characterizing CD8+ T cells

Notes

• This study characterizes an escape mutation in a C-terminal flanking residue of the HLA-A3 gag p17 KK9 epitope that inhibits processing, and is embedded in the overlapping HLA-A3 RK9 epitope.
• The immune response was tracked in subject AC-38. The acute immunodominant response was to the B57 TW10 epitope; this response declined following viral escape (tsNlqeqigw) by day 64. The p17 KK9 and RK9 became immunodominant, but then declined as the escape mutation arose. Three other strong responses that persisted were detected, along with 1 sub-dominant response to GY9.

References

Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.

Displaying record number 53204

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HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	(147-155 B consensus)
Epitope	ISPRTLNAW	Epitope Alignment
Epitope Name	IW9
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	characterizing CD8+ T cells

Notes

• This study characterizes an escape mutation in a C-terminal flanking residue of the HLA-A3 gag p17 KK9 epitope that inhibits processing, and is embedded in the overlapping HLA-A3 RK9 epitope.
• The immune response was tracked in subject AC-38. The acute immunodominant response was to the B57 TW10 epitope; this response declined following viral escape (tsNlqeqigw) by day 64. The p17 KK9 and RK9 became immunodominant, but then declined as the escape mutation arose. IW9 is 1 of 3 other strong responses that persisted, along with 1 sub-dominant response.

References

Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.

Displaying record number 53205

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HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	(162-172 B consensus)
Epitope	KAFSPEVIPMF	Epitope Alignment
Epitope Name	KF11
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	immunodominance, characterizing CD8+ T cells

Notes

• This study characterizes an escape mutation in a C-terminal flanking residue of the HLA-A3 gag p17 KK9 epitope that inhibits processing, and is embedded in the overlapping HLA-A3 RK9 epitope.
• The immune response was tracked in subject AC-38. The acute immunodominant response was to the B57 TW10 epitope; this response declined following viral escape (tsNlqeqigw) by day 64. The p17 KK9 and RK9 became immunodominant, but then declined as the escape mutation arose. FK11 is 1 of 3 other strong responses that persisted, along with 1 sub-dominant response.

References

Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.

Displaying record number 53203

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HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	( B consensus)
Epitope	TSTLQEQIGW	Epitope Alignment
		Show epitope variants
Epitope Name	TW10
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	United Kingdom
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	immunodominance, escape, characterizing CD8+ T cells

Notes

• This study characterizes an escape mutation in a C-terminal flanking residue of the HLA-A3 gag p17 KK9 epitope that inhibits processing, and is embedded in the overlapping HLA-A3 RK9 epitope.
• The immune response was tracked in subject AC-38. The acute immunodominant response was to the B57 TW10 epitope; this response declined following viral escape (tsNlqeqigw) by day 64. The p17 KK9 and RK9 became immunodominant, but then declined as the escape mutation arose. TW10 is 1 of 3 other strong responses that persisted, along with 1 sub-dominant response.

References

Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.