Search CTL/CD8+ T-Cell Epitope Database

Found 15 matching records:

Displaying record number 57972

HXB2 Location	Gag(20-28) p17(20-28) DNA(847..873)	Gag Epitope Map
Author Location	p17(20-28)
Epitope	RLRPGGKKK	Epitope Alignment
Epitope Name	RK9
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• RLRPGGKKK was one of 15 immunodominant responses identified, and a T-cell line was isolated from a A03-positive progressor patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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Displaying record number 57973

HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	p24(15-23)
Epitope	ISPRTLNAW	Epitope Alignment
Epitope Name	IW9
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• ISPRTLNAW was one of 15 immunodominant responses identified, and a T-cell line was isolated from a B57-positive progressor patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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Displaying record number 57980

HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	p24(30-40)
Epitope	KAFSPEVIPMF	Epitope Alignment
Epitope Name	KF11
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• KAFSPEVIPMF was one of 15 immunodominant responses identified, and a T-cell line was isolated from a B57-positive controller patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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Displaying record number 57978

HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	p24(30-40)
Epitope	KAFSPEVIPMF	Epitope Alignment
Epitope Name	KF11
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• KAFSPEVIPMF was one of 15 immunodominant responses identified, and a T-cell line was isolated from a B57-positive controller patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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Displaying record number 57974

HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	p24(30-40)
Epitope	KAFSPEVIPMF	Epitope Alignment
Epitope Name	KF11
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• KAFSPEVIPMF was one of 15 immunodominant responses identified, and a T-cell line was isolated from a B57-positive progressor patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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Displaying record number 57975

HXB2 Location	Gag(203-212) p24(71-80) DNA(1396..1425)	Gag Epitope Map
Author Location	p24(71-80)
Epitope	ETINEEAAEW	Epitope Alignment
Epitope Name	EW10
Subtype	B
Species (MHC/HLA)	human(B53)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• ETINEEAAEW was one of 15 immunodominant responses identified, and a T-cell line was isolated from a B53-positive progressor patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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Displaying record number 57963

HXB2 Location	Gag(216-224) p24(84-92) DNA(1435..1461)	Gag Epitope Map
Author Location	p24(84-92)
Epitope	HPVHAGPIA	Epitope Alignment
Epitope Name	HA9
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• HPVHAGPIA was one of 15 immunodominant responses identified, and a T-cell line was isolated from a B7-positive progressor patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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Displaying record number 57981

HXB2 Location	Gag(240-250) p24(108-118) DNA(1507..1539)	Gag Epitope Map
Author Location	p24(108-118)
Epitope	TSTLQEQIGWF	Epitope Alignment
Epitope Name	TF11
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• TSTLQEQIGWF was one of 15 immunodominant responses identified, and a T-cell line was isolated from a B57-positive controller patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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Displaying record number 57976

HXB2 Location	Gag(240-250) p24(108-118) DNA(1507..1539)	Gag Epitope Map
Author Location	p24(108-118)
Epitope	TSTLQEQIGWF	Epitope Alignment
Epitope Name	TF11
Subtype	B
Species (MHC/HLA)	human(B58)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• TSTLQEQIGWF was one of 15 immunodominant responses identified, and a T-cell line was isolated from a B58-positive controller patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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Displaying record number 57977

HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	p24(131-140)
Epitope	KRWIILGLNK	Epitope Alignment
Epitope Name	KK10
Subtype	B
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• KRWIILGLNK was one of 15 immunodominant responses identified, and a T-cell line was isolated from a B27-positive controller patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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Displaying record number 57979

HXB2 Location	Gag(308-316) p24(176-184) DNA(1711..1737)	Gag Epitope Map
Author Location	p24(176-184)
Epitope	QASQEVKNW	Epitope Alignment
Epitope Name	QW9
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• QASQEVKNW was one of 15 immunodominant responses identified, and a T-cell line was isolated from a B57-positive controller patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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Displaying record number 57969

HXB2 Location	Gag(433-442) p2p7p1p6(70-79) DNA(2086..2115)	Gag Epitope Map
Author Location	p2p7p1p6(70-79)
Epitope	FLGKIWPSYK	Epitope Alignment
Epitope Name	FK10
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• FLGKIWPSYK was one of 15 immunodominant responses identified, and a T-cell line was isolated from a A2-positive progressor patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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Displaying record number 57971

HXB2 Location	Pol(262-270) RT(107-115) DNA(2868..2894)	Pol Epitope Map
Author Location	RT(107-115)
Epitope	TVLDVGDAY	Epitope Alignment
Epitope Name	TY9
Subtype	B
Species (MHC/HLA)	human(B35)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• TVLDVGDAY was one of 15 immunodominant responses identified, and a T-cell line was isolated from a B35-positive progressor patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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Displaying record number 57970

HXB2 Location	Pol(283-290) RT(128-135) DNA(2931..2954)	Pol Epitope Map
Author Location	RT(128-135)
Epitope	TAFTIPSI	Epitope Alignment
Epitope Name	TI8
Subtype	B
Species (MHC/HLA)	human(B51)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• TAFTIPSI was one of 15 immunodominant responses identified, and a T-cell line was isolated from a B51-positive progressor patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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Displaying record number 57968

HXB2 Location	Nef(77-85) DNA(9025..9051)	Nef Epitope Map
Author Location	Nef(77-85)
Epitope	RPMTYKAAL	Epitope Alignment
Epitope Name	RL9
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	immunodominance, elite controllers

Notes

• Immunodominant responses were identified from progressors and controllers. Epitope-specific CD8 T-cell lines from progressors and controllers had similar effector function profiles in intracellular cytokine staining assays. In contrast, CD8 T-cell lines derived from controllers showed enhanced virus suppression when compared with progressors. Virus suppression was mediated in an MHC-dependent manner and found to correlate with a polyfunctional IL-2+ CD8 T-cell response.
• RPMTYKAAL was one of 15 immunodominant responses identified, and a T-cell line was isolated from a B7-positive progressor patient who was highly responsive to it.

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.

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