Search CTL/CD8+ T-Cell Epitope Database

Found 25 matching records:

Displaying record number 52480

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HXB2 Location	Gag(16-30) p17(16-30) DNA(835..879)	Gag Epitope Map
Author Location	p17(16-30 HXB2)
Epitope	WEKIRLRPGGKKKYK	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• Responses to this peptide were detected in 19% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52483

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HXB2 Location	Gag(71-85) p17(71-85) DNA(1000..1044)	Gag Epitope Map
Author Location	p17(71-85 HXB2)
Epitope	GSEELRSLYNTVATL	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 were chronically infected and treated; 22 started treatment during acute infection; 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• Responses to this peptide were detected in 16% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52468

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HXB2 Location	Gag(143-157) p24(11-25) DNA(1216..1260)	Gag Epitope Map
Author Location	p24(11-25 HXB2)
Epitope	VHQAISPRTLNAWVK	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• The authors did not note the reference strain, but based on the peptide sequences provided it appears to be HXB2.
• Responses to this peptide were detected in 29% of the study subjects, and it was the third most frequently recognized peptide.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52470

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HXB2 Location	Gag(163-176) p24(31-44) DNA(1276..1317)	Gag Epitope Map
Author Location	p24(31-44 HXB2)
Epitope	AFSPEVIPMFSALS	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• The authors did not note the reference strain, but based on the peptide sequences provided, it appears to be HXB2.
• Responses to this peptide were detected in 22% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52484

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HXB2 Location	Gag(167-181) p24(35-49) DNA(1288..1332)	Gag Epitope Map
Author Location	p24(35-48 HXB2)
Epitope	EVIPMFSALSEGATP	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• Responses to this peptide were detected in 16% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52471

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HXB2 Location	Gag(196-212) p24(64-80) DNA(1375..1425)	Gag Epitope Map
Author Location	p24(63-80 HXB2)
Epitope	AAMQMLKETINEEAAEW	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• The authors did not note the reference strain, but based on the peptide sequences provided it appears to be HXB2.
• Responses to this peptide were detected in 22% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52475

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HXB2 Location	Gag(253-267) p24(121-135) DNA(1546..1590)	Gag Epitope Map
Author Location	p24(121-135 HXB2)
Epitope	NPPIPVGEIYKRWII	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• The authors did not note the reference strain, but based on the peptide sequences provided it appears to be HXB2.
• Responses to this peptide were detected in 19% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52476

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HXB2 Location	Gag(258-272) p24(126-140) DNA(1561..1605)	Gag Epitope Map
Author Location	p24(126-140 HXB2)
Epitope	VGEIYKRWIIGLNK	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• The authors did not note the reference strain, but based on the peptide sequences provided it appears to be HXB2.
• Responses to this peptide were detected in 19% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52485

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HXB2 Location	Gag(263-277) p24(131-145) DNA(1576..1620)	Gag Epitope Map
Author Location	p24(131-145 HXB2)
Epitope	KRWIILGLNKIVRMY	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• Responses to this peptide were detected in 16% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52486

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HXB2 Location	Gag(268-282) p24(136-150) DNA(1591..1635)	Gag Epitope Map
Author Location	p24(136-150 HXB2)
Epitope	LGLNKIVRMYSPTSI	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized---the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized. A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• Responses to this peptide were detected in 16% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52487

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HXB2 Location	Gag(293-306) p24(161-174) DNA(1666..1707)	Gag Epitope Map
Author Location	p24(161-174 HXB2)
Epitope	FRDYVDRFYKTLRA	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• Responses to this peptide were detected in 16% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52477

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HXB2 Location	Gag(297-310) p24(165-178) DNA(1678..1719)	Gag Epitope Map
Author Location	p24(165-177 HXB2)
Epitope	VDRFYKTLRAEQAS	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• The authors did not note the reference strain, but based on the peptide sequences provided it appears to be HXB2.
• Responses to this peptide were detected in 19% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52481

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HXB2 Location	Gag(301-317) p24(169-185) DNA(1690..1740)	Gag Epitope Map
Author Location	p24(169-184 HXB2)
Epitope	YKTLRAEQASQDVKNWN	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• Responses to this peptide were detected in 17% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52488

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HXB2 Location	Gag(429-443) p2p7p1p6(66-80) DNA(2074..2118)	Gag Epitope Map
Author Location	p15(66-80)
Epitope	RQANFLGKIWPSYKG	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• Responses to this peptide were detected in 16% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52478

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HXB2 Location	Pol(306-323) RT(151-168) DNA(3000..3053)	Pol Epitope Map
Author Location	RT(151-168 HXB2)
Epitope	QGWKGSPAIFQSSMTKIL	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• The authors did not note the reference strain, but based on the peptide sequences provided it appears to be HXB2.
• Responses to this peptide were detected in 19% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52489

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HXB2 Location	Pol(395-412) RT(240-257) DNA(3267..3320)	Pol Epitope Map
Author Location	RT(240-257 HXB2)
Epitope	TVQPIVLPEKDSWTVNDI	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• Responses to this peptide were detected in 16% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52473

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HXB2 Location	Pol(528-545) RT(373-390) DNA(3666..3719)	Pol Epitope Map
Author Location	RT(373-390 HXB2)
Epitope	QKIATESIVIWGKTPKFK	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• The authors did not note the reference strain, but based on the peptide sequences provided it appears to be HXB2.
• Responses to this peptide were detected in 21% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52474

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HXB2 Location	Pol(933-950) Integrase(218-235) DNA(4881..4934)	Pol Epitope Map
Author Location	RT-Integrase(218-235 HXB2)
Epitope	TKIQNFRVYYRDSRDPLW	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• The authors did not note the reference strain, but based on the peptide sequences provided it appears to be HXB2.
• Responses to this peptide were detected in 21% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52482

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HXB2 Location	Vpr(25-40) DNA(5631..5678)	Vpr Epitope Map
Author Location	Vpr(25-40 HXB2)
Epitope	ELKNEAVRHFPRIWLH	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• Responses to this peptide were detected in 17% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52467

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HXB2 Location	Nef(70-84) DNA(9004..9048)	Nef Epitope Map
Author Location	Nef(70-84 HXB2)
Epitope	VTPQVPLRPMTYKAA	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• The authors did not note the reference strain, but based on the peptide sequences provided it appears to be HXB2.
• Responses to this peptide were detected in 34% of the study subjects, and it was the second most frequently recognized peptide.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52466

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HXB2 Location	Nef(80-94) DNA(9034..9078)	Nef Epitope Map
Author Location	Nef(80-94 HXB2)
Epitope	TYKAAVDLSHFLKEK	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• The authors did not note the reference strain, but based on the peptide sequences provided it appears to be HXB2.
• Responses to this peptide were detected in 47% of the study subjects, and it was the most frequently recognized peptide.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52490

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HXB2 Location	Nef(90-104) DNA(9064..9108)	Nef Epitope Map
Author Location	Nef(90-105 HXB2)
Epitope	FLKEKGGLEGLIHSQ	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• Responses to this peptide were detected in 16% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52479

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HXB2 Location	Nef(105-119) DNA(9109..9153)	Nef Epitope Map
Author Location	Nef(105-119 HXB2)
Epitope	RRQDILDLWIYHTQG	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• The authors did not note the reference strain, but based on the peptide sequences provided it appears to be HXB2.
• Responses to this peptide were detected in 19% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52472

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HXB2 Location	Nef(115-129) DNA(9139..9183)	Nef Epitope Map
Author Location	Nef(115-129 HXB2)
Epitope	YHTQGYFPDWQNYTP	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• The authors did not note the reference strain, but based on the peptide sequences provided it appears to be HXB2.
• Responses to this peptide were detected in 22% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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Displaying record number 52469

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HXB2 Location	Nef(130-144) DNA(9184..9228)	Nef Epitope Map
Author Location	Nef(130-144 HXB2)
Epitope	GPGVRYPLTFGWCYK	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	T-cell Elispot
Keywords	supervised treatment interruptions (STI), immunodominance, early treatment

Notes

• Comprehensive Elispot screening of 504 overlapping peptides that spanned all HIV-1 proteins in 57 HIV-1 infected individuals. Four groups of patients were compared: 23 were untreated; 12 patients were chronically infected and treated; 22 started treatment during acute infection, 11 continuously treated and 11 with STI.
• 63% of the peptides were recognized - the most frequent responses were directed against Nef (95%) and p24-Gag (88%). p17 was the most frequently recognized protein after correction for protein length. A median of 18 peptides (range 2-42) were recognized per person. The most frequently (>20%) recognized peptides were located in conserved regions within clade B sequences. Vpu was rarely recognized.
• A decrease in the total magnitude and in the breadth of CTL responses was detected in patients with treated acute infection in comparison to chronically infected treated or untreated individuals. No correlation between plasma viral load and HIV-1 specific T-cell responses was observed.
• The authors did not note the reference strain, but based on the peptide sequences provided it appears to be HXB2.
• Responses to this peptide were detected in 24% of the study subjects, and it was one of the 25 most frequently recognized peptides.

References

Addo2003 M. M. Addo, X. G. Yu, A. Rathod, D. Cohen, R. L. Eldridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, David R. Stone, C. Brander, P. J. R. Goulder, E. S. Rosenberg, M. Altfeld, and B. D. Walker. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol., 77(3):2081-2092, Feb 2003. PubMed ID: 12525643. Show all entries for this paper.

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