Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 762

HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	gp160(318-327 IIIB)
Epitope	`RGPGRAFVTI`	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Vaccine type	vaccinia
Vaccine strain	B clade IIIB
Vaccine component	gp160

Notes

Individual was immunized with rec vaccinia gp160 IIIB and boosted with purified gp160.
Lysis only occurs with IIIB P18 peptide pulsed onto autologous targets; MN, RF, SIMI P18 peptides fail to stimulate CTL.
Restimulating immune cells from gp160 IIIB vaccinees with MN, RF, or SIMI P18 did not enhance the MN, RF, or SIMI specific CTL response.

References

Achour1996 A. Achour, F. Bex, P. Hermans, A. Burny, and D. Zagury. Induction of anti-gp160 cytotoxic T cells cross-reacting with various V3 loop P18 peptides in human immunodeficiency virus type 1 envelope-immunized individuals. J. Virol., 70:6741-6750, 1996. PubMed ID: 8794311. Show all entries for this paper.

Displaying record number 764

HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	gp160(318-327 SIMI)
Epitope	`MGPKRAFYAT`	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Vaccine type	vaccinia prime with gp160 boost
Vaccine strain	B clade SIMI
Vaccine component	gp160

Notes

Individual was immunized with rec vaccinia gp160 SIMI and boosted with purified recombinant gp160 SIMI.
P18 MN and RF peptides were able to stimulate the HIV-specific CTL that arose in response to the SIMI vaccination, thus the P18 MN peptide (IGPGRAFYTT) and the P18 RF peptide (KGPGRVIYAT) could cross-react.
The P18 IIIB peptide does not cross-react (RGPGRAFVTI in the epitope region)
gp160 SIMI primed immune cells could generate a significantly broader specificity when stimulated with P18 MN or P18RF peptides, but not P18 IIIB.