HIV molecular immunology database

 

Search Antibody Database

Found 3 matching records:

Displaying record number 3509

Download this epitope record as JSON.

MAb ID N6
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope (Discontinuous epitope)
Subtype B
Ab Type gp120 CD4BS
Neutralizing P (tier 2)  View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human
Patient Z258
Immunogen HIV-1 infection
Keywords antibody binding site, antibody generation, antibody interactions, antibody lineage, antibody sequence, binding affinity, broad neutralizer, computational epitope prediction, contact residues, escape, immunotherapy, junction or fusion peptide, neutralization, review, structure, vaccine antigen design, vaccine-induced immune responses

Notes

Showing 11 of 11 notes.

References

Showing 11 of 11 references.

Isolation Paper
Huang2016a Jinghe Huang, Byong H. Kang, Elise Ishida, Tongqing Zhou, Trevor Griesman, Zizhang Sheng, Fan Wu, Nicole A. Doria-Rose, Baoshan Zhang, Krisha McKee, Sijy O'Dell, Gwo-Yu Chuang, Aliaksandr Druz, Ivelin S. Georgiev, Chaim A. Schramm, Anqi Zheng, M. Gordon Joyce, Mangaiarkarasi Asokan, Amy Ransier, Sam Darko, Stephen A. Migueles, Robert T. Bailer, Mark K. Louder, S. Munir Alam, Robert Parks, Garnett Kelsoe, Tarra Von Holle, Barton F. Haynes, Daniel C. Douek, Vanessa Hirsch, Michael S. Seaman, Lawrence Shapiro, John R. Mascola, Peter D. Kwong, and Mark Connors. Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth. Immunity, 45(5):1108-1121, 15 Nov 2016. PubMed ID: 27851912. Show all entries for this paper.

Bricault2019 Christine A. Bricault, Karina Yusim, Michael S. Seaman, Hyejin Yoon, James Theiler, Elena E. Giorgi, Kshitij Wagh, Maxwell Theiler, Peter Hraber, Jennifer P. Macke, Edward F. Kreider, Gerald H. Learn, Beatrice H. Hahn, Johannes F. Scheid, James M. Kovacs, Jennifer L. Shields, Christy L. Lavine, Fadi Ghantous, Michael Rist, Madeleine G. Bayne, George H. Neubauer, Katherine McMahan, Hanqin Peng, Coraline Chéneau, Jennifer J. Jones, Jie Zeng, Christina Ochsenbauer, Joseph P. Nkolola, Kathryn E. Stephenson, Bing Chen, S. Gnanakaran, Mattia Bonsignori, LaTonya D. Williams, Barton F. Haynes, Nicole Doria-Rose, John R. Mascola, David C. Montefiori, Dan H. Barouch, and Bette Korber. HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design. Cell Host Microbe, 25(1):59-72.e8, 9 Jan 2019. PubMed ID: 30629920. Show all entries for this paper.

Chuang2019 Gwo-Yu Chuang, Jing Zhou, Priyamvada Acharya, Reda Rawi, Chen-Hsiang Shen, Zizhang Sheng, Baoshan Zhang, Tongqing Zhou, Robert T. Bailer, Venkata P. Dandey, Nicole A. Doria-Rose, Mark K. Louder, Krisha McKee, John R. Mascola, Lawrence Shapiro, and Peter D. Kwong. Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition. Structure, 27(1):196-206.e6, 2 Jan 2019. PubMed ID: 30471922. Show all entries for this paper.

Guzzo2018 Christina Guzzo, Peng Zhang, Qingbo Liu, Alice L. Kwon, Ferzan Uddin, Alexandra I. Wells, Hana Schmeisser, Raffaello Cimbro, Jinghe Huang, Nicole Doria-Rose, Stephen D. Schmidt, Michael A. Dolan, Mark Connors, John R. Mascola, and Paolo Lusso. Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation. mBio, 9(6), 11 Dec 2018. PubMed ID: 30538178. Show all entries for this paper.

Julg2017 Boris Julg, Amarendra Pegu, Peter Abbink, Jinyan Liu, Amanda Brinkman, Katherine Molloy, Shanell Mojta, Abishek Chandrashekar, Katherine Callow, Keyun Wang, Xuejun Chen, Stephen D. Schmidt, Jinghe Huang, Richard A. Koup, Michael S. Seaman, Brandon F. Keele, John R. Mascola, Mark Connors, and Dan H. Barouch. Virological Control by the CD4-Binding Site Antibody N6 in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys. J. Virol., 91(16), 15 Aug 2017. PubMed ID: 28539448. Show all entries for this paper.

Kwon2018 Young D. Kwon, Gwo-Yu Chuang, Baoshan Zhang, Robert T. Bailer, Nicole A. Doria-Rose, Tatyana S. Gindin, Bob Lin, Mark K. Louder, Krisha McKee, Sijy O'Dell, Amarendra Pegu, Stephen D. Schmidt, Mangaiarkarasi Asokan, Xuejun Chen, Misook Choe, Ivelin S. Georgiev, Vivian Jin, Marie Pancera, Reda Rawi, Keyun Wang, Rajoshi Chaudhuri, Lisa A. Kueltzo, Slobodanka D. Manceva, John-Paul Todd, Diana G. Scorpio, Mikyung Kim, Ellis L. Reinherz, Kshitij Wagh, Bette M. Korber, Mark Connors, Lawrence Shapiro, John R. Mascola, and Peter D. Kwong. Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody. Cell Rep., 22(7):1798-1809, 13 Feb 2018. PubMed ID: 29444432. Show all entries for this paper.

Kwong2018 Peter D. Kwong and John R. Mascola. HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure. Immunity, 48(5):855-871, 15 May 2018. PubMed ID: 29768174. Show all entries for this paper.

Schommers2020 Philipp Schommers, Henning Gruell, Morgan E. Abernathy, My-Kim Tran, Adam S. Dingens, Harry B. Gristick, Christopher O. Barnes, Till Schoofs, Maike Schlotz, Kanika Vanshylla, Christoph Kreer, Daniela Weiland, Udo Holtick, Christof Scheid, Markus M. Valter, Marit J. van Gils, Rogier W. Sanders, Jörg J. Vehreschild, Oliver A. Cornely, Clara Lehmann, Gerd Fätkenheuer, Michael S. Seaman, Jesse D. Bloom, Pamela J. Bjorkman, and Florian Klein. Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody. Cell, 180(3):471-489.e22, 6 Feb 2020. PubMed ID: 32004464. Show all entries for this paper.

Wagh2018 Kshitij Wagh, Michael S. Seaman, Marshall Zingg, Tomas Fitzsimons, Dan H. Barouch, Dennis R. Burton, Mark Connors, David D. Ho, John R. Mascola, Michel C. Nussenzweig, Jeffrey Ravetch, Rajeev Gautam, Malcolm A. Martin, David C. Montefiori, and Bette Korber. Potential of Conventional \& Bispecific Broadly Neutralizing Antibodies for Prevention of HIV-1 Subtype A, C \& D Infections. PLoS Pathog., 14(3):e1006860, Mar 2018. PubMed ID: 29505593. Show all entries for this paper.

Walker2018 Laura M. Walker and Dennis R. Burton. Passive Immunotherapy of Viral Infections: `Super-Antibodies' Enter the Fray. Nat. Rev. Immunol., 18(5):297-308, May 2018. PubMed ID: 29379211. Show all entries for this paper.

Zhang2022 Baoshan Zhang, Jason Gorman, Sijy O’Dell, Leland F. Damron, Krisha McKee, Mangaiarkarasi Asokan, Amarendra Pegu, Bob C. Lin, Cara W. Chao, Xuejun Chen, Lucio Gama, Vera B. Ivleva, William H. Law, Cuiping Liu, Mark K. Louder, Stephen D. Schmidt, Chen-Hsiang Shen, Wei Shi, Judith A. Stein, Michael S. Seaman, Adrian B. McDermott, Kevin Carlton, John R. Mascola, Peter D. Kwong, Q. Paula Lei, and Nicole A. Doria-Rose. Engineering of {HIV-1} Neutralizing Antibody {CAP256V2LS} for Manufacturability and Improved Half Life, , :, 22 Apr 2022. Show all entries for this paper.


Displaying record number 3510

Download this epitope record as JSON.

MAb ID F8
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Ab Type gp120 CD4BS
Neutralizing P (tier 2)
Species (Isotype) human
Patient Z258
Immunogen HIV-1 infection
Keywords antibody generation, antibody sequence, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Huang2016a Jinghe Huang, Byong H. Kang, Elise Ishida, Tongqing Zhou, Trevor Griesman, Zizhang Sheng, Fan Wu, Nicole A. Doria-Rose, Baoshan Zhang, Krisha McKee, Sijy O'Dell, Gwo-Yu Chuang, Aliaksandr Druz, Ivelin S. Georgiev, Chaim A. Schramm, Anqi Zheng, M. Gordon Joyce, Mangaiarkarasi Asokan, Amy Ransier, Sam Darko, Stephen A. Migueles, Robert T. Bailer, Mark K. Louder, S. Munir Alam, Robert Parks, Garnett Kelsoe, Tarra Von Holle, Barton F. Haynes, Daniel C. Douek, Vanessa Hirsch, Michael S. Seaman, Lawrence Shapiro, John R. Mascola, Peter D. Kwong, and Mark Connors. Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth. Immunity, 45(5):1108-1121, 15 Nov 2016. PubMed ID: 27851912. Show all entries for this paper.


Displaying record number 3511

Download this epitope record as JSON.

MAb ID N17
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Ab Type gp120 CD4BS
Neutralizing P (tier 2)
Species (Isotype) human
Patient Z258
Immunogen HIV-1 infection
Keywords antibody generation, antibody sequence, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Huang2016a Jinghe Huang, Byong H. Kang, Elise Ishida, Tongqing Zhou, Trevor Griesman, Zizhang Sheng, Fan Wu, Nicole A. Doria-Rose, Baoshan Zhang, Krisha McKee, Sijy O'Dell, Gwo-Yu Chuang, Aliaksandr Druz, Ivelin S. Georgiev, Chaim A. Schramm, Anqi Zheng, M. Gordon Joyce, Mangaiarkarasi Asokan, Amy Ransier, Sam Darko, Stephen A. Migueles, Robert T. Bailer, Mark K. Louder, S. Munir Alam, Robert Parks, Garnett Kelsoe, Tarra Von Holle, Barton F. Haynes, Daniel C. Douek, Vanessa Hirsch, Michael S. Seaman, Lawrence Shapiro, John R. Mascola, Peter D. Kwong, and Mark Connors. Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth. Immunity, 45(5):1108-1121, 15 Nov 2016. PubMed ID: 27851912. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health