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MAb ID | 5G7D8 | |
---|---|---|
HXB2 Location | Tat(49-86) DNA(5975..6045,8379..8421) |
Tat Epitope Map |
Author Location | Tat | |
Epitope |
RKKRRQRRRPPQGSQTHQVSLSKQPTSQSRGDPTGPKE
|
Epitope Alignment |
Ab Type | C-term | |
Neutralizing | ||
Species (Isotype) | mouse(IgG1) | |
Patient | ||
Immunogen | vaccine | |
Keywords |
Vaccine type | protein |
---|---|
Vaccine component | Tat |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Valvatne1996 H. Valvatne, A. M. Szilvay, and D. E. Helland. A Monoclonal Antibody Defines a Novel HIV Type 1 Tat Domain Involved in Trans-Cellular Trans-Activation. AIDS Res. Hum. Retroviruses, 12:611-619, 1996. CAT and beta-galactosidase assays, and immunofluorescence analysis were used to study the cellular uptake of the HIV-1 Tat protein. A MAb binding to the basic domain and the RGD sequence inhibits trans- activation by exogenous Tat. The inhibition of the cellular uptake of Tat by an anti-Tat monoclonal antibody and by the serum components implies specific binding of Tat to the cell membrane. PubMed ID: 8743086. Show all entries for this paper.
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