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MAb ID | 7C3 | |
---|---|---|
HXB2 Location | Pol(977-986) DNA(5013..5042) |
Pol Epitope Map |
Author Location | Integrase(262-271 HXB2) | |
Epitope |
RRKAKIIRDY
|
Epitope Alignment
|
Subtype | B | |
Ab Type | ||
Neutralizing | ||
Species (Isotype) | mouse(IgG1κ) | |
Patient | ||
Immunogen | vaccine | |
Keywords |
Vaccine type | protein |
---|---|
Vaccine strain | B clade HXB2 |
Vaccine component | Int |
Showing 2 of 2 notes.
Showing 2 of 2 references.
Haugan1995 I. R. Haugan, B. M. Nilsen, S. Worland, L. Olsen, and D. E. Helland. Characterization of the DNA-Binding Activity of HIV-1 Integrase Using a Filter Binding Assay. Biochem. Biophys. Res. Commun., 217:802-810, 1995. PubMed ID: 8554601. Show all entries for this paper.
Nilsen1996 B. M. Nilsen, I. R. Haugan, K. Berg, L. Olsen, P. O. Brown, and D. E. Helland. Monoclonal Antibodies against Human Immunodeficiency Virus Type 1 Integrase: Epitope Mapping and Differential Effects of Integrase Activities In Vitro. J. Virol., 70:1580-1587, 1996. In this study, 17 anti-integrase murine Mabs were generated and epitopes were mapped by deletion mutations and peptide scanning. The ability of MAb binding to inhibit (or stimulate) end-processing, DNA joining, reintegration, and disintegration enzyme functions it in vitro was determined. PubMed ID: 8627677. Show all entries for this paper.
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