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HIV Molecular Immunology Database

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Displaying record number 104

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MAb ID 23A5G4
HXB2 Location Gag(285-304)
DNA(1642..1701)
Gag Epitope Map
Author Location p24(285-304 IIIB)
Epitope IRQGPKEPFRDYVDRFYKTL Epitope Alignment
IRQGPKEPFRDYVDRFYKTL epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component p24 Gag

Notes

Showing 2 of 2 notes.

References

Showing 3 of 3 references.

Janvier1990 B. Janvier, P. Archinard, B. Mandrand, A. Goudeau, and F. Barin. Linear B-Cell Epitopes of the Major Core Protein of Human Immunodeficiency Virus Types 1 and 2. J. Virol., 64:4258-4263, 1990. PubMed ID: 1696638. Show all entries for this paper.

Janvier1992 B. Janvier, P. Archinard, B. Mandrand, A. Goudeau, and F. Barin. Linear B-Cell Epitopes of the Major Core Protein of Human Immunodeficiency Virus Types 1 and 2 (Author's Correction). J. Virol., 66:613, 1992. Show all entries for this paper.

Janvier1996 B. Janvier, J. J. Lasarte, P. Sarobe, J. Hoebeke, A. Baillou-Beaufils F. Borras-Cuesta, and F. Barin. B-Cell Epitopes of HIV Type 1 p24 Capsid Protein: A Reassessment. AIDS Res. Hum. Retroviruses, 12:519-525, 1996. The reactivity pattern of 45 overlapping synthetic pentadecapeptides, spanning amino acids 133 to 363 (p24) of HIV-1 p55 gag precursor, using sera from 20 HIV-1 positive and 8 HIV negative individuals was determined by ELISA. A peptide covering aa 178-192 was recognized by 40\%, and a peptide covering 288-302 of p55 by 45\%, of HIV-1 positive people. A peptide covering aa 272-322 of p55 was recognized by most human sera. A conformational epitope involving sequences from aa 183-186 and 289-292 was proposed, based by analogy to the structure of the Mengovirus VP2 protein. PubMed ID: 8679307. Show all entries for this paper.


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