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Displaying record number 806

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MAb ID	120-16 (SZ-120.16)
HXB2 Location	gp160(644-663) DNA(8154..8213)	gp160 Epitope Map
Author Location	gp41(644-663 HXB2)
Epitope	SLIEESQNQQEKNEQELLEL	Epitope Alignment
Subtype	B
Ab Type	gp41 MPER (membrane proximal external region)
Neutralizing
Species (Isotype)	human(IgG2κ)
Patient	donor_uncoded_3
Immunogen	HIV-1 infection
Keywords	ADCC, review

Notes

Showing 3 matching of 9 total notes.

• 120-16: The complexity of the epitopes recognized by ADCC responses in HIV-1 infected individuals and candidate vaccine recipients is discussed in this review. 120-16 is discussed as the MPER region-targeting, non-neutralizing anti-gp41 mAb with a linear epitope, exhibiting the most potent ADCC activity and mapped to AA 644-663(Table-1). Pollara2013 (ADCC, review)
• 120-16: No neutralizing activity, both ADCC and viral enhancing activity. Epitope numbering is provided as gp160 644-663, but no details are given. Forthal1995 (ADCC)
• 120-16: Potent ADCC (in contrast to MAb 98-43, gp41(579-604)). Tyler1990 (ADCC)

References

Showing 3 matching of 10 total references.

Forthal1995 D. N. Forthal, G. Landucci, M. K. Gorny, S. Zolla-Pazner, and W. E. Robinson, Jr. Functional Activities of 20 Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Human Monoclonal Antibodies. AIDS Res. Hum. Retroviruses, 11:1095-1099, 1995. A series of tests were performed on 20 human monoclonal antibodies to assess their potential therapeutic utility. Antibodies were tested for potentially harmful complement-mediated antibody enhancing activity (C-ADE), and for potentially beneficial neutralizing activity and antibody dependent cellular cytotoxicity ADCC. PubMed ID: 8554906. Show all entries for this paper.

Pollara2013 Justin Pollara, Mattia Bonsignori, M. Anthony Moody, Marzena Pazgier, Barton F. Haynes, and Guido Ferrari. Epitope Specificity of Human Immunodeficiency Virus-1 Antibody Dependent Cellular Cytotoxicity (ADCC) Responses. Curr. HIV Res., 11(5):378-387, Jul 2013. PubMed ID: 24191939. Show all entries for this paper.

Tyler1990 D. S. Tyler, S. D. Stanley, S. Zolla-Pazner, M. K. Gorny, P. P. Shadduck, A. J. Langlois, T. J. Matthews, D. P. Bolognesi, T. J. Palker, and K. J. Weinhold. Identification of sites within gp41 that serve as targets for antibody-dependent cellular cytotoxicity by using human monoclonal antibodies. J. Immunol., 145:3276-3282, 1990. PubMed ID: 1700004. Show all entries for this paper.