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Displaying record number 565

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MAb ID	42F
HXB2 Location	gp160(491-500) DNA(7695..7724)	gp160 Epitope Map
Author Location	gp120(491-500 HXB2)
Epitope	IEPLGVAPTK	Epitope Alignment
Subtype	B
Ab Type	gp120 C5
Neutralizing
Species (Isotype)	human(IgG1λ)
Patient
Immunogen	HIV-1 infection
Keywords	ADCC, review

Notes

Showing 3 matching of 4 total notes.

• 42F: The complexity of the epitopes recognized by ADCC responses in HIV-1 infected individuals and candidate vaccine recipients is discussed in this review. 42F is discussed as the C5-targeting, non-neutralizing anti-gp120 mAb exhibiting ADCC activity and having a linear epitope. Pollara2013 (ADCC, review)
• 42F: A study of 6 anti-Env MAbs and their ability to bind or direct ADCC against target cells infected with IIIB, MN, SF-2, and RF -- bound and directed lysis against strains IIIB, MN, SF-2, and RF, but not a clone of MN. Alsmadi1998 (ADCC)
• 42F: 42F and 43F were isolated from a long term non-progressor by EBV transformation of PBMC -- samples were taken 14 months apart -- both MAbs stained diverse strains of infected cells and directed ADCC -- were more potent for ADCC if the cell was infected with HIV-1, rather than just presenting absorbed gp120. Alsmadi1997 (ADCC)

References

Showing 3 matching of 4 total references.

Alsmadi1997 O. Alsmadi, R. Herz, E. Murphy, A. Pinter, and S. A. Tilley. A novel antibody-dependent cellular cytotoxicity epitope in gp120 is identified by two monoclonal antibodies isolated from a long-term survivor of human immunodeficiency virus type 1 infection. J. Virol., 71:925-33, 1997. PubMed ID: 8995609. Show all entries for this paper.

Alsmadi1998 O. Alsmadi and S. A. Tilley. Antibody-dependent cellular cytotoxicity directed against cells expressing human immunodeficiency virus type 1 Envelope of primary or laboratory-adapted strains by human and chimpanzee monoclonal antibodies of different epitope specificities. J. Virol., 72:286-93, 1998. PubMed ID: 9420226. Show all entries for this paper.

Pollara2013 Justin Pollara, Mattia Bonsignori, M. Anthony Moody, Marzena Pazgier, Barton F. Haynes, and Guido Ferrari. Epitope Specificity of Human Immunodeficiency Virus-1 Antibody Dependent Cellular Cytotoxicity (ADCC) Responses. Curr. HIV Res., 11(5):378-387, Jul 2013. PubMed ID: 24191939. Show all entries for this paper.