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Displaying record number 506

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MAb ID	694/98-D (694/98, 694.8, 694/98D, 694-98D)
HXB2 Location	gp160(314-317) DNA(7164..7175)	gp160 Epitope Map
Author Location	gp120( IIIB)
Research Contact	Dr. Zolla-Pazner, Veterans Affairs Center, NY, NY. zollas01@endeavor.med.nyu.edu
Epitope	GRAF	Epitope Alignment
Subtype	B
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing	L
Species (Isotype)	human(IgG1λ)
Patient
Immunogen	HIV-1 infection
Keywords	ADCC, review

Notes

Showing 2 matching of 36 total notes.

• 694/98D: The complexity of the epitopes recognized by ADCC responses in HIV-1 infected individuals and candidate vaccine recipients is discussed in this review. 694/98D is discussed as the V3 region-targeting, neutralizing anti-gp120 mAb exhibiting ADCC activity and having a linear epitope. Pollara2013 (ADCC, review)
• 694/98-D: ADCC activity, and no viral enhancing activity. Epitope provided as GPAF, but no details are given. Forthal1995 (ADCC)

References

Showing 2 matching of 39 total references.

Forthal1995 D. N. Forthal, G. Landucci, M. K. Gorny, S. Zolla-Pazner, and W. E. Robinson, Jr. Functional Activities of 20 Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Human Monoclonal Antibodies. AIDS Res. Hum. Retroviruses, 11:1095-1099, 1995. A series of tests were performed on 20 human monoclonal antibodies to assess their potential therapeutic utility. Antibodies were tested for potentially harmful complement-mediated antibody enhancing activity (C-ADE), and for potentially beneficial neutralizing activity and antibody dependent cellular cytotoxicity ADCC. PubMed ID: 8554906. Show all entries for this paper.

Pollara2013 Justin Pollara, Mattia Bonsignori, M. Anthony Moody, Marzena Pazgier, Barton F. Haynes, and Guido Ferrari. Epitope Specificity of Human Immunodeficiency Virus-1 Antibody Dependent Cellular Cytotoxicity (ADCC) Responses. Curr. HIV Res., 11(5):378-387, Jul 2013. PubMed ID: 24191939. Show all entries for this paper.