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MAb ID	41148D
HXB2 Location	gp160(305-313) DNA(7137..7163)	gp160 Epitope Map
Author Location	gp120( MN)
Epitope	KRIHIGP	Epitope Alignment
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing	L
Species (Isotype)	human(IgG1)
Patient
Immunogen	HIV-1 infection
Keywords	ADCC, review

Notes

Showing 2 matching of 5 total notes.

• 41148D: The complexity of the epitopes recognized by ADCC responses in HIV-1 infected individuals and candidate vaccine recipients is discussed in this review. 41148D is discussed as the V3 region-targeting, neutralizing anti-gp120 mAb exhibiting ADCC activity and having a linear epitope. Pollara2013 (ADCC, review)
• 41148D: A study of 6 anti-Env MAbs and their ability to bind or direct ADCC against target cells infected with IIIB, MN, SF-2, and RF -- bound and directed lysis against strains IIIB, MN, SF-2, comparable to 4117C, however 41148D is 10x less efficient at neutralization, showing ADCC and neutralization don't always correlate. Alsmadi1998 (ADCC)

References

Showing 2 matching of 5 total references.

Alsmadi1998 O. Alsmadi and S. A. Tilley. Antibody-dependent cellular cytotoxicity directed against cells expressing human immunodeficiency virus type 1 Envelope of primary or laboratory-adapted strains by human and chimpanzee monoclonal antibodies of different epitope specificities. J. Virol., 72:286-93, 1998. PubMed ID: 9420226. Show all entries for this paper.

Pollara2013 Justin Pollara, Mattia Bonsignori, M. Anthony Moody, Marzena Pazgier, Barton F. Haynes, and Guido Ferrari. Epitope Specificity of Human Immunodeficiency Virus-1 Antibody Dependent Cellular Cytotoxicity (ADCC) Responses. Curr. HIV Res., 11(5):378-387, Jul 2013. PubMed ID: 24191939. Show all entries for this paper.