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Displaying record number 3634

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MAb ID	M785-U1
HXB2 Location	gp160	gp160 Epitope Map
Author Location	gp41
Research Contact	G. K. Lewis, University of Maryland
Epitope
Ab Type	gp41
Neutralizing
Species (Isotype)
Patient
Immunogen
Keywords	ADCC

Notes

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M785-U1: The results confirm that Nef and Vpu protect HIV-1-infected cells from ADCC, but also show that not all classes of antibody can mediate ADCC. Anti-cluster-A antibodies are able to mediate potent ADCC responses, whereas anti-coreceptor binding site antibodies are not. Position 69 in gp120 is important for antibody-mediated cellular toxicity by anti-cluster-A antibodies. The angle of approach of a given class of antibodies could impact its capacity to mediate ADCC. F240, N5-U1, N5-U3, N10-U1, M785-U1, and 7B2 were selected Abs that recognize gp41. Ding2015 (ADCC)

References

Showing 1 matching of 2 total references.

Ding2015 Shilei Ding, Maxime Veillette, Mathieu Coutu, Jérémie Prévost, Louise Scharf, Pamela J. Bjorkman, Guido Ferrari, James E. Robinson, Christina Stürzel, Beatrice H. Hahn, Daniel Sauter, Frank Kirchhoff, George K. Lewis, Marzena Pazgier, and Andrés Finzi. A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies. J. Virol., 90(4):2127-2134, Feb 2016. PubMed ID: 26637462. Show all entries for this paper.