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Displaying record number 2392

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MAb ID	5-25
HXB2 Location	Env	Env Epitope Map
Author Location	gp41
Epitope
Ab Type	gp41 cluster I
Neutralizing	no
Species (Isotype)	human(IgG)
Patient	Patient 5
Immunogen	HIV-1 infection
Keywords	ADCC, binding affinity

Notes

Showing 1 matching of 5 total notes.

5-25: A panel of antibodies was tested for binding, stability, and ADCC activity on HIV-infected cells. The differences in killing efficiency were linked to changes in binding of the antibody and the accessibility of the Fc region when bound to infected cells. Ab 5-25 was used as a control antibody with strong ADCC activity, but not broadly neutralizing. Bruel2016 (ADCC, binding affinity)

References

Showing 1 matching of 5 total references.

Bruel2016 Timothée Bruel, Florence Guivel-Benhassine, Sonia Amraoui, Marine Malbec, Léa Richard, Katia Bourdic, Daniel Aaron Donahue, Valérie Lorin, Nicoletta Casartelli, Nicolas Noël, Olivier Lambotte, Hugo Mouquet, and Olivier Schwartz. Elimination of HIV-1-Infected Cells by Broadly Neutralizing Antibodies. Nat. Commun., 7:10844, 3 Mar 2016. PubMed ID: 26936020. Show all entries for this paper.