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Displaying record number 1625

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type
Neutralizing
Species (Isotype)	chimpanzee
Patient
Immunogen	vaccine
Keywords	ADCC, neutralization, subtype comparisons, vaccine antigen design, variant cross-reactivity

Vaccine Details

Vaccine type	other
Vaccine strain	B clade MN, B clade SF162
Vaccine component	Env, gp140ΔV2, Rev
Adjuvant	MF59

Notes

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Chimpanzees were immunized with Ad5- and Ad7-HIVenv/rev recombinant prime and gp140deltaV2 protein boost in MF59 adjuvant. The vaccine induced high titers of subtype A, B, C and CRF01_AE gp120-binding Abs. Most of the sera cross-neutralized a heterologous subtype C isolate but not other A, C and CRF01_AE isolates. The vaccine also elicited cross-clade ADCC activity against subtypes A, B, C and CRF01_AE in the majority of sera. Gomez-Roman2006 (ADCC, neutralization, vaccine antigen design, variant cross-reactivity, subtype comparisons)

References

Showing 1 of 1 reference.

Gomez-Roman2006 V. Raúl Gómez-Román, Ruth H. Florese, Bo Peng, David C. Montefiori, Vaniambadi S. Kalyanaraman, David Venzon, Indresh Srivastava, Susan W. Barnett, and Marjorie Robert-Guroff. An Adenovirus-Based HIV Subtype B Prime/Boost Vaccine Regimen Elicits Antibodies Mediating Broad Antibody-Dependent Cellular Cytotoxicity Against Non-Subtype B HIV Strains. J. Acquir. Immune Defic. Syndr., 43(3):270-277, 1 Nov 2006. PubMed ID: 16940858. Show all entries for this paper.