Search Antibody Database

Found 1 matching record:

Displaying record number 1275

Download this epitope record as JSON.

MAb ID	1125H (1125h)
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Research Contact	Shermaine Tilley, Public Health Research Institute, USA
Epitope	(Discontinuous epitope)
Subtype	B
Ab Type	gp120 CD4BS
Neutralizing	L (MN)
Species (Isotype)	human(IgG1κ)
Patient	donor 1125
Immunogen	HIV-1 infection
Keywords	ADCC, review

Notes

Showing 2 matching of 16 total notes.

1125H: The complexity of the epitopes recognized by ADCC responses in HIV-1 infected individuals and candidate vaccine recipients is discussed in this review. 1125H is discussed as the CD4bs-targeting, neutralizing anti-gp120 mAb exhibiting ADCC activity and having a discontinuous epitope. Pollara2013 (ADCC, review)
1125H: A study of 6 anti-Env MAbs and their ability to bind or direct ADCC against target cells infected with IIIB, MN, SF-2, and RF -- bound and directed lysis against all four strains. Alsmadi1998 (ADCC)

References

Showing 2 matching of 16 total references.

Alsmadi1998 O. Alsmadi and S. A. Tilley. Antibody-dependent cellular cytotoxicity directed against cells expressing human immunodeficiency virus type 1 Envelope of primary or laboratory-adapted strains by human and chimpanzee monoclonal antibodies of different epitope specificities. J. Virol., 72:286-93, 1998. PubMed ID: 9420226. Show all entries for this paper.

Pollara2013 Justin Pollara, Mattia Bonsignori, M. Anthony Moody, Marzena Pazgier, Barton F. Haynes, and Guido Ferrari. Epitope Specificity of Human Immunodeficiency Virus-1 Antibody Dependent Cellular Cytotoxicity (ADCC) Responses. Curr. HIV Res., 11(5):378-387, Jul 2013. PubMed ID: 24191939. Show all entries for this paper.