HIV molecular immunology database


Search Antibody Database

Found 1 matching record:

Displaying record number 3508

Download this epitope record as JSON.

MAb ID 10E8v4
HXB2 Location gp160(671-683)
gp160 Epitope Map
Author Location gp160
Epitope NWFDISNWLWYIK Epitope Alignment
NWFDISNWLWYIK epitope logo
Subtype B
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG3)
Patient Donor N152
Immunogen engineered
Keywords antibody binding site, antibody generation, binding affinity, neutralization, structure, vaccine antigen design


Showing 3 of 3 notes.


Showing 3 of 3 references.

Isolation Paper
Kwon2016 Young D. Kwon, Ivelin S. Georgiev, Gilad Ofek, Baoshan Zhang, Mangaiarkarasi Asokan, Robert T. Bailer, Amy Bao, William Caruso, Xuejun Chen, Misook Choe, Aliaksandr Druz, Sung-Youl Ko, Mark K. Louder, Krisha McKee, Sijy O'Dell, Amarendra Pegu, Rebecca S. Rudicell, Wei Shi, Keyun Wang, Yongping Yang, Mandy Alger, Michael F. Bender, Kevin Carlton, Jonathan W. Cooper, Julie Blinn, Joshua Eudailey, Krissey Lloyd, Robert Parks, S. Munir Alam, Barton F. Haynes, Neal N. Padte, Jian Yu, David D. Ho, Jinghe Huang, Mark Connors, Richard M Schwartz, John R. Mascola, and Peter D. Kwong. Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design. J. Virol., 90(13):5899-5914, 1 Jul 2016. PubMed ID: 27053554. Show all entries for this paper.

Kwon2018 Young D. Kwon, Gwo-Yu Chuang, Baoshan Zhang, Robert T. Bailer, Nicole A. Doria-Rose, Tatyana S. Gindin, Bob Lin, Mark K. Louder, Krisha McKee, Sijy O'Dell, Amarendra Pegu, Stephen D. Schmidt, Mangaiarkarasi Asokan, Xuejun Chen, Misook Choe, Ivelin S. Georgiev, Vivian Jin, Marie Pancera, Reda Rawi, Keyun Wang, Rajoshi Chaudhuri, Lisa A. Kueltzo, Slobodanka D. Manceva, John-Paul Todd, Diana G. Scorpio, Mikyung Kim, Ellis L. Reinherz, Kshitij Wagh, Bette M. Korber, Mark Connors, Lawrence Shapiro, John R. Mascola, and Peter D. Kwong. Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody. Cell Rep., 22(7):1798-1809, 13 Feb 2018. PubMed ID: 29444432. Show all entries for this paper.

Xu2017 Ling Xu, Amarendra Pegu, Ercole Rao, Nicole Doria-Rose, Jochen Beninga, Krisha McKee, Dana M. Lord, Ronnie R. Wei, Gejing Deng, Mark Louder, Stephen D. Schmidt, Zachary Mankoff, Lan Wu, Mangaiarkarasi Asokan, Christian Beil, Christian Lange, Wulf Dirk Leuschner, Jochen Kruip, Rebecca Sendak, Young Do Kwon, Tongqing Zhou, Xuejun Chen, Robert T. Bailer, Keyun Wang, Misook Choe, Lawrence J. Tartaglia, Dan H. Barouch, Sijy O'Dell, John-Paul Todd, Dennis R. Burton, Mario Roederer, Mark Connors, Richard A. Koup, Peter D. Kwong, Zhi-Yong Yang, John R. Mascola, and Gary J. Nabel. Trispecific Broadly Neutralizing HIV Antibodies Mediate Potent SHIV Protection in Macaques. Science, 358(6359):85-90, 6 Oct 2017. PubMed ID: 28931639. Show all entries for this paper.

Questions or comments? Contact us at
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health