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Displaying record number 3417

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MAb ID	DH276
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120
Neutralizing	P (tier 1)
Species (Isotype)	human(IgG1)
Patient	CH9105
Immunogen	HIV-1 infection
Country	Malawi
Keywords	antibody binding site, antibody generation, antibody polyreactivity, antibody sequence

Notes

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DH276: A panel of Env-specific mAbs was isolated from 6 HIV1-infected lactating women. Antibodies in colostrum may help prevent mucosal infection of the infant, so this study aimed to define milk IgGs for future vaccination strategies to reduce HIV transmission during lactation. Despite the high rate of VH 1-69 usage among colostrum Env specific B cells, it did not correlate with distinct gp120 epitope specificity or function. Antibody DH276 was isolated from colostrum and recognized gp120. It was able to neutralize 4 tier-1 viral strains, but not tier 2. It inhibited EC-virus interaction, inhibited DC virus transfer, had ADCC activity, and cross-reacted with gut bacteria. Jeffries2016 (antibody binding site, antibody generation, antibody sequence, antibody polyreactivity)

References

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Isolation Paper
Jeffries2016 T. L. Jeffries, Jr., C. R. Sacha, J. Pollara, J. Himes, F. H. Jaeger, S. M. Dennison, E. McGuire, E. Kunz, J. A. Eudailey, A. M. Trama, C. LaBranche, G. G. Fouda, K. Wiehe, D. C. Montefiori, B. F. Haynes, H.-X. Liao, G. Ferrari, S. M. Alam, M. A. Moody, and S. R. Permar. The Function and Affinity Maturation of HIV-1 gp120-Specific Monoclonal Antibodies Derived from Colostral B Cells. Mucosal. Immunol., 9(2):414-427, Mar 2016. PubMed ID: 26242599. Show all entries for this paper.