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MAb ID C108G (C108g, c108g)
HXB2 Location gp160(162-169)
gp160 Epitope Map
Author Location gp120(162-169 HXB2)
Research Contact S. Tilley, Public Health Research Institute, NY, NY
Epitope STSIRGKV Epitope Alignment
STSIRGKV epitope logo
Subtype B
Ab Type gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing L
Species (Isotype) chimpanzee(IgG1κ)
Immunogen HIV-1 infection
Keywords ADCC, antibody binding site, antibody generation, antibody interactions, antibody sequence, neutralization, review, variant cross-reactivity


Showing 13 of 13 notes.


Showing 13 of 13 references.

Isolation Paper
Warrier1994 S. V. Warrier, A. Pinter, W. J. Honnen, M. Girard, E. Muchmore, and S. A. Tilley. A Novel, Glycan-Dependent Epitope in the V2 Domain of Human Immunodeficiency Virus Type 1 gp120 Is Recognized by a Highly Potent, Neutralizing Chimpanzee Monoclonal Antibody. J. Virol., 68:4636-4642, 1994. PubMed ID: 7515975. Show all entries for this paper.

Alsmadi1998 O. Alsmadi and S. A. Tilley. Antibody-dependent cellular cytotoxicity directed against cells expressing human immunodeficiency virus type 1 Envelope of primary or laboratory-adapted strains by human and chimpanzee monoclonal antibodies of different epitope specificities. J. Virol., 72:286-93, 1998. PubMed ID: 9420226. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: LA-UR 04-8162. Show all entries for this paper.

Honnen2007 W. J. Honnen, C. Krachmarov, S. C. Kayman, M. K. Gorny, S. Zolla-Pazner, and A. Pinter. Type-Specific Epitopes Targeted by Monoclonal Antibodies with Exceptionally Potent Neutralizing Activities for Selected Strains of Human Immunodeficiency Virus Type 1 Map to a Common Region of the V2 Domain of gp120 and Differ Only at Single Positions from the Clade B Consensus Sequence. J. Virol., 81(3):1424-1432, Feb 2007. PubMed ID: 17121806. Show all entries for this paper.

Mondor1998 I. Mondor, S. Ugolini, and Q. J. Sattentau. Human Immunodeficiency Virus Type 1 Attachment to HeLa CD4 Cells Is CD4 Independent and Gp120 Dependent and Requires Cell Surface Heparans. J. Virol., 72:3623-3634, 1998. PubMed ID: 9557643. Show all entries for this paper.

ORourke2012 Sara M. O'Rourke, Becky Schweighardt, Pham Phung, Kathryn A. Mesa, Aaron L. Vollrath, Gwen P. Tatsuno, Briana To, Faruk Sinangil, Kay Limoli, Terri Wrin, and Phillip W. Berman. Sequences in Glycoprotein gp41, the CD4 Binding Site, and the V2 Domain Regulate Sensitivity and Resistance of HIV-1 to Broadly Neutralizing Antibodies. J. Virol., 86(22):12105-12114, Nov 2012. PubMed ID: 22933284. Show all entries for this paper.

Pinter2005 Abraham Pinter, William J. Honnen, Paul D'Agostino, Miroslaw K. Gorny, Susan Zolla-Pazner, and Samuel C. Kayman. The C108g Epitope in the V2 Domain of gp120 Functions as a Potent Neutralization Target When Introduced into Envelope Proteins Derived from Human Immunodeficiency Virus Type 1 Primary Isolates. J. Virol., 79(11):6909-6917, Jun 2005. PubMed ID: 15890930. Show all entries for this paper.

Sheppard2007a Neil C. Sheppard, Sarah L. Davies, Simon A. Jeffs, Sueli M. Vieira, and Quentin J. Sattentau. Production and Characterization of High-Affinity Human Monoclonal Antibodies to Human Immunodeficiency Virus Type 1 Envelope Glycoproteins in a Mouse Model Expressing Human Immunoglobulins. Clin. Vaccine Immunol., 14(2):157-167, Feb 2007. PubMed ID: 17167037. Show all entries for this paper.

Ugolini1997 S. Ugolini, I. Mondor, P. W. H. I Parren, D. R. Burton, S. A. Tilley, P. J. Klasse, and Q. J. Sattentau. Inhibition of Virus Attachment to CD4+ Target Cells Is a Major Mechanism of T Cell Line-Adapted HIV-1 Neutralization. J. Exp. Med., 186:1287-1298, 1997. PubMed ID: 9334368. Show all entries for this paper.

Vijh-Warrier1996 Sujata Vijh-Warrier, Abraham Pinter, William J. Honnen, and Shermaine A. Tilley. Synergistic Neutralization of Human Immunodeficiency Virus Type 1 by a Chimpanzee Monoclonal Antibody against the V2 Domain of gp120 in Combination with Monoclonal Antibodies against the V3 Loop and the CD4-Binding Site. J. Virol., 70(7):4466-4473, Jul 1996. PubMed ID: 8676471. Show all entries for this paper.

Walker2009a Laura M. Walker, Sanjay K. Phogat, Po-Ying Chan-Hui, Denise Wagner, Pham Phung, Julie L. Goss, Terri Wrin, Melissa D. Simek, Steven Fling, Jennifer L. Mitcham, Jennifer K. Lehrman, Frances H. Priddy, Ole A. Olsen, Steven M. Frey, Phillip W . Hammond, Protocol G Principal Investigators, Stephen Kaminsky, Timothy Zamb, Matthew Moyle, Wayne C. Koff, Pascal Poignard, and Dennis R. Burton. Broad and Potent Neutralizing Antibodies from an African Donor Reveal a new HIV-1 Vaccine Target. Science, 326(5950):285-289, 9 Oct 2009. PubMed ID: 19729618. Show all entries for this paper.

Warrier1995 S. V. Warrier, E. Murphy, I. Yokoyama, and S. A. Tilley. Characterization of the Variable Regions of a Chimpanzee Monoclonal Antibody with Potent Neutralizing Activity Against HIV-1. Mol. Immunol., 32:1081-1092, 1995. PubMed ID: 8544858. Show all entries for this paper.

Wu1995 Z. Wu, S. C. Kayman, W. Honnen, K. Revesz, H. Chen, S. V. Warrier, S. A. Tilley, J. McKeating, C. Shotton, and A. Pinter. Characterization of Neutralization Epitopes in the V2 Region of Human Immunodeficiency Virus Type 1 gp120: Role of Glycosylation in the Correct Folding of the V1/V2 Domain. J. Virol., 69:2271-2278, 1995. Most epitopes based only on numbering. PubMed ID: 7533854. Show all entries for this paper.

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