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Displaying record number 1593

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MAb ID KD-247
HXB2 Location gp160(311-315)
DNA(7155..7169)
gp160 Epitope Map
Author Location Env( MOKW)
Research Contact Shuzo Matsushita, Kumamoto University, Japan shuzo@kaiju.medic.kumamoto-u.ac.jp
Epitope IGPGR Epitope Alignment
IGPGR epitope logo
Subtype B
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) humanized mouse(IgG)
Patient  
Immunogen vaccine
Country Japan
Keywords ADCC, anti-idiotype, antibody binding site, antibody generation, antibody sequence, binding affinity, compensatory mutation, escape, glycosylation, immunoprophylaxis, immunotherapy, mimics, neutralization, review, structure, variant cross-reactivity, viral fitness and reversion

Vaccine Details

Vaccine type peptide
Vaccine strain B clade, B clade MN, B clade RF, other
Vaccine component Env V3
Adjuvant Complete Freund's Adjuvant (CFA), Incomplete Freund's Adjuvant (IFA)

Notes

Showing 14 of 14 notes.

References

Showing 14 of 14 references.

Isolation Paper
Eda2006a Yasuyuki Eda, Mari Takizawa, Toshio Murakami, Hiroaki Maeda, Kazuhiko Kimachi, Hiroshi Yonemura, Satoshi Koyanagi, Kouichi Shiosaki, Hirofumi Higuchi, Keiichi Makizumi, Toshihiro Nakashima, Kiyoshi Osatomi, Sachio Tokiyoshi, Shuzo Matsushita, Naoki Yamamoto, and Mitsuo Honda. Sequential Immunization with V3 Peptides from Primary Human Immunodeficiency Virus Type 1 Produces Cross-Neutralizing Antibodies against Primary Isolates with a Matching Narrow-Neutralization Sequence Motif. J. Virol., 80(11):5552-5562, Jun 2006. PubMed ID: 16699036. Show all entries for this paper.

Chen2009b Weizao Chen and Dimiter S. Dimitrov. Human Monoclonal Antibodies and Engineered Antibody Domains as HIV-1 Entry Inhibitors. Curr. Opin. HIV AIDS, 4(2):112-117, Mar 2009. PubMed ID: 19339949. Show all entries for this paper.

Eda2006 Yasuyuki Eda, Toshio Murakami, Yasushi Ami, Tadashi Nakasone, Mari Takizawa, Kenji Someya, Masahiko Kaizu, Yasuyuki Izumi, Naoto Yoshino, Shuzo Matsushita, Hirofumi Higuchi, Hajime Matsui, Katsuaki Shinohara, Hiroaki Takeuchi, Yoshio Koyanagi, Naoki Yamamoto, and Mitsuo Honda. Anti-V3 Humanized Antibody KD-247 Effectively Suppresses Ex Vivo Generation of Human Immunodeficiency Virus Type 1 and Affords Sterile Protection of Monkeys against a Heterologous Simian/Human Immunodeficiency Virus Infection. J. Virol., 80(11):5563-5570, Jun 2006. PubMed ID: 16699037. Show all entries for this paper.

Hatada2010 Makiko Hatada, Kazuhisa Yoshimura, Shigeyoshi Harada, Yoko Kawanami, Junji Shibata, and Shuzo Matsushita. Human Immunodeficiency Virus Type 1 Evasion of a Neutralizing Anti-V3 Antibody Involves Acquisition of a Potential Glycosylation Site in V2. J. Gen. Virol., 91(Pt 5):1335-1345, May 2010. PubMed ID: 20032207. Show all entries for this paper.

Kirby2015 Karen A. Kirby, Yee Tsuey Ong, Atsuko Hachiya, Thomas G. Laughlin, Leslie A. Chiang, Yun Pan, Jennifer .L Moran, Bruno Marchand, Kamalendra Singh, Fabio Gallazzi, Thomas P. Quinn, Kazuhisa Yoshimura, Toshio Murakami, Shuzo Matsushita, and Stefan G. Sarafianos. Structural Basis of Clade-Specific HIV-1 Neutralization by Humanized Anti-V3 Monoclonal Antibody KD-247. FASEB J., 29(1):70-80, Jan 2015. PubMed ID: 25351987. Show all entries for this paper.

Matsushita2005 Shuzo Matsushita, Soichiro Takahama, Junji Shibata, Tetsuya Kimura, Koichi Shiozaki, Yasuyuki Eda, Atsushi Koito, Toshio Murakami, and Kazuhisa Yoshimura. Ex Vivo Neutralization of HIV-1 Quasi-Species by a Broadly Reactive Humanized Monoclonal Antibody KD-247. Hum. Antibodies, 14(3-4):81-88, 2005. PubMed ID: 16720978. Show all entries for this paper.

Matsushita2015 Shuzo Matsushita, Kazuhisa Yoshimura, Kristel Paola Ramirez, Jaya Pisupati, Toshio Murakami, and KD-1002 Study Group. Passive Transfer of Neutralizing mAb KD-247 Reduces Plasma Viral Load in Patients Chronically Infected with HIV-1. AIDS, 29(4):453-462, 20 Feb 2015. PubMed ID: 25630040. Show all entries for this paper.

Murakami2009 Toshio Murakami, Yasuyuki Eda, Tadashi Nakasone, Yasushi Ami, Kenji Someya, Naoto Yoshino, Masahiko Kaizu, Yasuyuki Izumi, Hajime Matsui, Katsuaki Shinohara, Naoki Yamamoto, and Mitsuo Honda. Postinfection Passive Transfer of KD-247 Protects against Simian/Human Immunodeficiency Virus-Induced CD4+ T-Cell Loss in Macaque Lymphoid Tissue. AIDS, 23(12):1485-1494, 31 Jul 2009. PubMed ID: 19528788. Show all entries for this paper.

Ong2012 Y. T. Ong, K. A. Kirby, A. Hachiya, L. A. Chiang, B. Marchand, K. Yoshimura, T. Murakami, K. Singh, S. Matsushita, and S. G. Sarafianos. Preparation of Biologically Active Single-Chain Variable Antibody Fragments That Target the HIV-1 gp120 V3 Loop. Cell. Mol. Biol. (Noisy-le-grand), 58(1):71-79, 2012. PubMed ID: 23273194. Show all entries for this paper.

RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.

Shibata2007 Junji Shibata, Kazuhisa Yoshimura, Akiko Honda, Atsushi Koito, Toshio Murakami, and Shuzo Matsushita. Impact of V2 Mutations on Escape from a Potent Neutralizing Anti-V3 Monoclonal Antibody during In Vitro Selection of a Primary Human Immunodeficiency Virus Type 1 Isolate. J. Virol., 81(8):3757-3768, Apr 2007. PubMed ID: 17251298. Show all entries for this paper.

Takizawa2011 Mari Takizawa, Kosuke Miyauchi, Emiko Urano, Shigeru Kusagawa, Katsuhiko Kitamura, Satoshi Naganawa, Toshio Murakami, Mitsuo Honda, Naoki Yamamoto, and Jun Komano. Regulation of the Susceptibility of HIV-1 to a Neutralizing Antibody KD-247 by Nonepitope Mutations Distant from its Epitope. AIDS, 25(18):2209-2216, 28 Nov 2011. PubMed ID: 21866041. Show all entries for this paper.

Yoshimura2006 Kazuhisa Yoshimura, Junji Shibata, Tetsuya Kimura, Akiko Honda, Yosuke Maeda, Atsushi Koito, Toshio Murakami, Hiroaki Mitsuya, and Shuzo Matsushita. Resistance Profile of a Neutralizing Anti-HIV Monoclonal Antibody, KD-247, that Shows Favourable Synergism with Anti-CCR5 Inhibitors. AIDS, 20(16):2065-2073, 24 Oct 2006. PubMed ID: 17053352. Show all entries for this paper.

Yoshimura2010 Kazuhisa Yoshimura, Shigeyoshi Harada, Junji Shibata, Makiko Hatada, Yuko Yamada, Chihiro Ochiai, Hirokazu Tamamura, and Shuzo Matsushita. Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds. J. Virol., 84(15):7558-7568, Aug 2010. PubMed ID: 20504942. Show all entries for this paper.


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