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Displaying record number 433

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MAb ID 5025A (5025)
HXB2 Location gp160(313-317)
DNA(7161..7175)
gp160 Epitope Map
Author Location gp120(313-317 BH10)
Research Contact Paul Durda, Du Pont de Nemours and Co
Epitope PGRAF Epitope Alignment
PGRAF epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing L
Species (Isotype) mouse(IgG)
Patient  
Immunogen vaccine
Keywords antibody binding site, antibody generation, binding affinity

Vaccine Details

Vaccine type peptide
Vaccine strain B clade BH10
Vaccine component Env V3

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

DSouza1991 M. P. D'Souza, P. Durda, C. V. Hanson, G. Milman, and Collaborating Investigators. Evaluation of Monoclonal Antibodies to HIV-1 by Neutralization and Serological Assays: An International Collaboration. AIDS, 5:1061-1070, 1991. PubMed ID: 1718320. Show all entries for this paper.

Langedijk1991 J. P. M. Langedijk, N. K. T. Back, P. J. Durda, J. Goudsmit, and R. H. Meloen. Neutralizing activity of anti-peptide antibodies against the principal neutralization domain of human immunodeficiency virus type 1. J. Gen. Virol., 72:2519-2526, 1991. MAbs were raised against RIQRGPGRAFVTIGK by immunizing mice. Fine structure of MAb binding sites was mapped using pepscan. Preservation of the $\beta$ turn at the tip of the loop was critical. PubMed ID: 1919529. Show all entries for this paper.


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