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Displaying record number 442

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MAb ID	polyclonal
HXB2 Location	Gag(176-192) DNA(1315..1365)	Gag Epitope Map
Author Location	p24(176-192 LAI)
Epitope	`SEGATPQDLNTMLNTVG`	Epitope Alignment
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	protein, virus-like particle (VLP)
Vaccine strain	B clade LAI
Vaccine component	Gag, p17 Gag, p24 Gag
Adjuvant	Complete Freund's Adjuvant (CFA)

Notes

Showing 2 of 2 notes.

Similarity level of the polyclonal Ab binding site pentapeptide NTMLN to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 1 time, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
An ELISA assay was used to study a panel of Gag peptides -- mature p24 CA epitopes mapped to residues 176-192, 201-218, 233-253, 285-304, and were recognized by antibodies elicited by rp24CA -- one p17MA epitope, residues 11-25, and one p24CA epitope, residues 176-192, were recognized by antibodies raised against anti-p55 virus-like particles, suggesting different antigenic properties for p24CA and p17MA antibodies depending on whether they are produced against the mature soluble protein or the immature assembled form of the gag proteins. Truong1997

References

Showing 2 of 2 references.

Truong1997 C. Truong, D. Brand, F. Mallet, P. Roingeard, and F. Barin. Comparison of antibody responses to different forms of HIV-1 core antigens by epitope mapping. J. Med. Virol., 51(3):145--51, Mar 1997. PubMed ID: 9139076. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.