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Found 2 matching records:

Displaying record number 564

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MAb ID	polyclonal
HXB2 Location	gp160(503-509) DNA(7731..7751)	gp160 Epitope Map
Author Location	gp120(471-477)
Epitope	RRVVQRE	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

Showing 1 of 1 note.

• Mice were immunized with peptide APTKAKRRVVQREKR -- epitope excision and extraction combined with mass spectrometry was used to map the fine structure of epitopes recognized by polyclonal Ab to HIV-1 Env -- a major epitope was identified between positions 472 and 478. Jeyarajah1998

References

Showing 1 of 1 reference.

Jeyarajah1998 S. Jeyarajah, C. E. Parker, M. T. Summer, and K. B. Tomer. Matrix-assisted laser desorption ionization/mass spectrometry mapping of human immunodeficiency virus-gp120 epitopes recognized by a limited polyclonal antibody. J Am Soc Mass Spectrom, 9:157-65, 1998. PubMed ID: 9679595. Show all entries for this paper.

Displaying record number 583

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MAb ID	722-D
HXB2 Location	gp160(503-509) DNA(7731..7751)	gp160 Epitope Map
Author Location	gp120(503-509)
Epitope	RRVVQRE	Epitope Alignment
Ab Type	C-term
Neutralizing
Species (Isotype)	human(IgG1κ)
Patient
Immunogen	HIV-1 infection
Keywords	dendritic cells, neutralization

Notes

Showing 3 of 3 notes.

• 722-D: This Ab did not inhibit HIV-1 BaL replication in macrophages. Holl2006 (neutralization, dendritic cells)
• 722-D: No neutralizing activity, no ADCC activity, and no viral enhancing activity. Epitope numbering is provided as gp120 503-509, but no details are given. Forthal1995
• 722-D: Not neutralizing alone, could synergize anti-CD4 binding site antibody neutralization. Laal1994

References

Showing 3 of 3 references.

Laal1994 Suman Laal, Sherri Burda, Miroslav K. Gorny, Sylwia Karwowska, Aby Buchbinder, and Susan Zolla-Pazner. Synergistic Neutralization of Human Immunodeficiency Virus Type 1 by Combinations of Human Monoclonal Antibodies. J. Virol., 68(6):4001-4008, Jun 1994. PubMed ID: 7514683. Show all entries for this paper.

Forthal1995 D. N. Forthal, G. Landucci, M. K. Gorny, S. Zolla-Pazner, and W. E. Robinson, Jr. Functional Activities of 20 Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Human Monoclonal Antibodies. AIDS Res. Hum. Retroviruses, 11:1095-1099, 1995. A series of tests were performed on 20 human monoclonal antibodies to assess their potential therapeutic utility. Antibodies were tested for potentially harmful complement-mediated antibody enhancing activity (C-ADE), and for potentially beneficial neutralizing activity and antibody dependent cellular cytotoxicity ADCC. PubMed ID: 8554906. Show all entries for this paper.

Holl2006 Vincent Holl, Maryse Peressin, Thomas Decoville, Sylvie Schmidt, Susan Zolla-Pazner, Anne-Marie Aubertin, and Christiane Moog. Nonneutralizing Antibodies Are Able To Inhibit Human Immunodeficiency Virus Type 1 Replication in Macrophages and Immature Dendritic Cells. J. Virol., 80(12):6177-6181, Jun 2006. PubMed ID: 16731957. Show all entries for this paper.