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Displaying record number 529

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MAb ID	2H1B
HXB2 Location	gp160(357-362) DNA(7293..7310)	gp160 Epitope Map
Author Location	gp120(370-376 HIV2ROD)
Epitope	`RNISFKA`	Epitope Alignment
Subtype	HIV-2
Ab Type	gp120 C3
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	peptide
Vaccine strain	HIV-2 ROD

Notes

Showing 2 of 2 notes.

2H1B: Similarity level of the 2H1B binding site pentapeptide SFKA to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 4 times, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
2H1B: Binds in WB, but binds poorly to Env on the cell surface. Matsushita1995

References

Showing 2 of 2 references.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.

Matsushita1995 S. Matsushita, S. Matsumi, K. Yoshimura, T. Morikita, T. Murakami, and K. Takatsuki. Neutralizing monoclonal antibodies against human immunodeficiency virus type 2 gp120. J. Virol., 69:3333-3340, 1995. PubMed ID: 7538171. Show all entries for this paper.