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MAb ID	110.6
HXB2 Location	gp160(311-318) DNA(7155..7178)	gp160 Epitope Map
Author Location	gp120( BRU)
Epitope	`RGPGRAFV`	Epitope Alignment
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing	L (weak)
Species (Isotype)	mouse(IgG1λ)
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody interactions, binding affinity, optimal epitope

Vaccine Details

Vaccine type	HIV infected-cell lysate
Vaccine strain	B clade BRU
Vaccine component	HIV-1

Notes

Showing 2 of 2 notes.

110.6: mAbs binding to the tip of a loop on the principal neutralizing domain (PND) of HIV-1, strains LAV-1 and HTLV IIIB, were fine-mapped by Pepscan analysis to their optimal epitopes and their affinity studied. 110.3, 110.4 and 110.5 had the same specificities, binding to epitope IQRGPGRAF (amino acid 309-317). For 110.6, the core sequence was RGPGRAF (311-317). 110.6 had neutralizing activity 3x lower than 110.5. Langedijk1992 (antibody binding site, antibody interactions, optimal epitope, binding affinity)
110.6: Variable region sequenced -- heavy chain: V J558-146b.1alpha, D closest to DSP16.2, J H3 -- light chain: V lambda1, J lambda1. Pirofski1993

References

Showing 3 of 3 references.

Langedijk1992 J. P. M. Langedijk, N. K. T. Back, E. Kinney-Thomas, C. Bruck, M. Francotte, J. Goudsmit, and R. H. Meloen. Comparison and Fine Mapping of Both High and Low Neutralizing Monoclonal Antibodies against the Principal Neutralization Domain of HIV-1. Arch. Virol., 126:129-146, 1992. PubMed ID: 1381908. Show all entries for this paper.

Pirofski1993 L.-A. Pirofski, E. K. Thomas, and M. D. Scharff. Variable region gene utilization and mutation in a group of neutralizing murine anti-human immunodeficiency virus type 1 principal neutralizing determinant antibodies. AIDS Res. Hum. Retroviruses, 9:41-49, 1993. Observed restricted subset of murine V heavy and light chain gene elements in a set of 5 antibodies that bind to the tip of the V3 loop. PubMed ID: 7678971. Show all entries for this paper.

Thomas1988 E. Kinney Thomas, J. N. Weber, J. McClure, P. R. Clapham, M. C. Singhal, M. K. Shriver, and R. A. Weiss. Neutralizing Monoclonal Antibodies to the AIDS Virus. AIDS, 2:25-29, 1988. PubMed ID: 2451922. Show all entries for this paper.