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Displaying record number 493

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MAb ID	5042
HXB2 Location	gp160(310-316) DNA(7152..7172)	gp160 Epitope Map
Author Location	gp120
Epitope	`QRGPGRA`	Epitope Alignment
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing	L
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	peptide

Notes

Showing 1 of 1 note.

5042: Binding to native gp120 100-300 fold greater than to denatured -- 314G/W substitution abolishes binding, changes outside the loop have little effect. Moore1993c

References

Showing 3 of 3 reference.

Durda1988 P. J. Durda, B. Leece, A. M. Jenoski, H. Rabin, A. Fisher, R. Gallo, and F. Wong-Staal. Characterization of Murine Monoclonal Antibodies to HIV-1 Induced by Synthetic Peptides. AIDS Res. Hum. Retroviruses, 4:331-342, 1988. PubMed ID: 2848556. Show all entries for this paper.

Durda1990 P. J. Durda, L. Bacheler, P. Clapham, A. M. Jenoski, B. Leece, T. J. Matthews, A. McKnight, R. Pomerantz, M. Rayner, and K. J. Weinhold. HIV-1 Neutralizing Monoclonal Antibodies Induced by a Synthetic Peptide. AIDS Res. Hum. Retroviruses, 6:1115, 1990. PubMed ID: 1702301. Show all entries for this paper.

Moore1993c J. P. Moore, M. Thali, B. A. Jameson, F. Vignaux, G. K. Lewis, S.-W. Poon, M. S. Fung, P. J. Durda, L. Akerblom, B. Wahren, D. D. Ho, Q. J. Sattentau, and J. Sodroski. Immunochemical Analysis of the gp120 Surface Glycoprotein of Human Immunodeficiency Virus Type 1: Probing the Structure of the C4 and V4 Domains and the Interaction of the C4 Domain with the V3 Loop. J. Virol., 73:4785-4796, 1993. General observations: C4 and V3 MAbs are sensitive to the way the epitopes are presented, and this sensitivity cannot be correlated to peptide binding. Some V3-C4 domain interaction was indicated based on mutation and interference studies. PubMed ID: 7687303. Show all entries for this paper.