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MAb ID | 5042A | |
---|---|---|
HXB2 Location | Env(310-315) DNA(7152..7169) |
Env Epitope Map |
Author Location | gp120(310-315 BH10) | |
Epitope |
QRGPGR
|
Epitope Alignment
|
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | L | |
Species (Isotype) | mouse(IgG) | |
Patient | ||
Immunogen | vaccine | |
Keywords | antibody binding site, antibody generation, binding affinity |
Vaccine type | peptide |
---|---|
Vaccine strain | B clade BH10 |
Vaccine component | Env V3 |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Langedijk1991 J. P. M. Langedijk, N. K. T. Back, P. J. Durda, J. Goudsmit, and R. H. Meloen. Neutralizing activity of anti-peptide antibodies against the principal neutralization domain of human immunodeficiency virus type 1. J. Gen. Virol., 72:2519-2526, 1991. MAbs were raised against RIQRGPGRAFVTIGK by immunizing mice. Fine structure of MAb binding sites was mapped using pepscan. Preservation of the $\beta$ turn at the tip of the loop was critical. PubMed ID: 1919529. Show all entries for this paper.
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