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Displaying record number 432

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MAb ID 5042A
HXB2 Location gp160(310-315)
gp160 Epitope Map
Author Location gp120(310-315 BH10)
Epitope QRGPGR Epitope Alignment
QRGPGR epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing L
Species (Isotype) mouse(IgG)
Immunogen vaccine
Keywords antibody binding site, antibody generation, binding affinity

Vaccine Details

Vaccine type peptide
Vaccine strain B clade BH10
Vaccine component Env V3


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Showing 1 of 1 reference.

Langedijk1991 J. P. M. Langedijk, N. K. T. Back, P. J. Durda, J. Goudsmit, and R. H. Meloen. Neutralizing activity of anti-peptide antibodies against the principal neutralization domain of human immunodeficiency virus type 1. J. Gen. Virol., 72:2519-2526, 1991. MAbs were raised against RIQRGPGRAFVTIGK by immunizing mice. Fine structure of MAb binding sites was mapped using pepscan. Preservation of the $\beta$ turn at the tip of the loop was critical. PubMed ID: 1919529. Show all entries for this paper.

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