HIV molecular immunology database
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|gp160 Epitope Map|
|Author Location||gp41(596-599 IIIB)|
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Lopalco1993 L. Lopalco, R. Longhi, F. Ciccomascolo, A. De Rossi, M. Pelagi, F. Andronico, J. P. Moore, B T. Schulz, A. Beretta, and A. G. Siccardi. Identification of human immunodeficiency virus type 1 glycoprotein gp120/gp41 interacting sites by the idiotypic mimicry of two monoclonal antibodies. AIDS Res. Hum. Retroviruses, 9:33-39, 1993. The MAb M38 binds to the carboxy terminus of gp120, in a gp41 binding region. This MAb was used to create an anti-idiotype MAb, 9G5A, which can bind to gp41 at the base of the cysteine loop. The binding domains of these two monoclonals are consistent with the C5 domain of gp120 being able to bind to the gp41 cysteine loop. The MAb M38 also binds to human HLA molecules, in antigenic homology or possibly molecular mimicry. PubMed ID: 7678970. Show all entries for this paper.