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Displaying record number 909

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MAb ID	polyclonal
HXB2 Location	Nef(118-133) DNA(9148..9195)	Nef Epitope Map
Author Location	Nef(118-133)
Epitope	`QGYFPDWQNYTPGPGV`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	DNA
Vaccine strain	B clade BRU
Vaccine component	Nef

Notes

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BALB/c mice were immunized with a pBN-vector expressing HIV-1 nef, rev, or tat genes---DNA loaded onto gold microparticles was delivered using a gene gun, and DNA dissolved in saline was given intradermally or intramuscularly---Nef gene gun immunized mice showed the strongest and most long-lasting (6 months) Ab, CTL and proliferative responses---the highest IgG1/IgG2a ratio was observed in the gene gun immunized mice---three Ab binding sites were found in Nef using peptide mapping, although some sera reacted only to complete Nef---Rev- or Tat-immunized mice did not generate an Ab response. Tahtinen2001

References

Showing 1 of 1 reference.

Tahtinen2001 M. Tahtinen, M. Strengell, A. Collings, J. Pitkanen, A. Kjerrstrom, K. Hakkarainen, P. Peterson, B. Kohleisen, B. Wahren, A. Ranki, M. Ustav, and K. Krohn. DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating pBN-vector. Vaccine, 19(15--16):2039--47, 28 Feb 2001. PubMed ID: 11228375. Show all entries for this paper.