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Displaying record number 535

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MAb ID	5C2E5
HXB2 Location	gp160(422-431) DNA(7488..7517)	gp160 Epitope Map
Author Location	gp120(406-415 IIIB)
Research Contact	T. Gregory and R. Ward, Genentech, San Francisco
Epitope	QFINMWQEVK	Epitope Alignment
Ab Type	gp120 C4
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

Showing 3 of 3 notes.

• 5C2E5: Similarity level of the 5C2E5 binding site pentapeptide MWQEV to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 0 times, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
• 5C2E5: Cross-competition with MAbs 5C2E5, ICR38.8f and ICR38.1a. Cordell1991
• 5C2E5: Blocks the gp120-CD4 interaction. Lasky1987

References

Showing 3 of 3 references.

Lasky1987 L. A. Lasky, G. Nakamura, D. H. Smith, C. Fennie, C. Shimasaki, E. Patzer, P. Berman, T. Gregory, and D. J. Capon. Delineation of a Region of the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein Critical for Interaction with the CD4 Receptor. Cell, 50:975-985, 1987. PubMed ID: 2441877. Show all entries for this paper.

Cordell1991 J. Cordell, J. P. Moore, C. J. Dean, P. J. Klasse, R. A. Weiss, and J. A. McKeating. Rat Monoclonal Antibodies to Nonoverlapping Epitopes of Human Immunodeficiency Virus Type I gp120 Block CD4 Binding In Vitro. Virology, 185:72-79, 1991. PubMed ID: 1718090. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.