Search Antibody Database

Found 10 matching records:

Displaying record number 1068

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MAb ID	46E3/E6
HXB2 Location	gp160(139-155) DNA(6639..6689)	gp160 Epitope Map
Author Location	gp120(gp120 )
Research Contact	Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org
Epitope	NTKSSNWKEMDGEIK	Epitope Alignment
Ab Type	gp120 V1
Neutralizing
Species (Isotype)	transgenic mouse(IgG2κ)
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, review, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade SF162
Vaccine component	gp120
Adjuvant	Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 2 of 2 notes.

• 46E3/E6: In an extensive review of gp120 binding MAbs in this database, V1-specific MAbs are noted to be unusual, but in one study transgenic mouse immunization with SF162 yielded ten V1 MAbs with highly strain-specific autologous NAb responses, and V1 was immunodominant. Human MAbs to V1 may be difficult to isolate due to selection with heterologous strains. Gorny2003 (variant cross-reactivity, review)
• 46E3/E6: Transgenic mice (strain XenoMouse G2) carrying human genes allowing production of fully human IgG2kappa MAbs were used to rapidly create a panel of anti-HIV gp120 MAb-producing hybridomas by immunization with HIV SF162 gp120 -- several of the MAbs obtained were effective at neutralizing the autologous strain -- C-term-V1- region was immunodominant in these mice and the ten V1-specific MAbs could potently neutralize autologous strain SF162 but were highly type specific. He2002 (antibody binding site, antibody generation)

References

Showing 2 of 2 references.

Isolation Paper
He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.

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Displaying record number 1069

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MAb ID	82D3/C3
HXB2 Location	gp160(139-155) DNA(6639..6689)	gp160 Epitope Map
Author Location	gp120(gp120 )
Research Contact	Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org
Epitope	NTKSSNWKEMDGEIK	Epitope Alignment
Ab Type	gp120 V1
Neutralizing
Species (Isotype)	transgenic mouse(IgG2κ)
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, review, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade SF162
Vaccine component	gp120
Adjuvant	Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 2 of 2 notes.

• 82D3/C3: In an extensive review of gp120 binding MAbs in this database, V1-specific MAbs are noted to be unusual, but in one study transgenic mouse immunization with SF162 yielded ten V1 MAbs with highly strain-specific autologous NAb responses, and V1 was immunodominant. Human MAbs to V1 may be difficult to isolate due to selection with heterologous strains. Gorny2003 (variant cross-reactivity, review)
• 82D3/C3: Transgenic mice (strain XenoMouse G2) carrying human genes allowing production of fully human IgG2kappa MAbs were used to rapidly create a panel of anti-HIV gp120 MAb-producing hybridomas by immunization with HIV SF162 gp120 -- several of the MAbs obtained were effective at neutralizing the autologous strain -- C-term-V1- region was immunodominant in these mice and the ten V1-specific MAbs could potently neutralize autologous strain SF162 but were highly type specific. He2002 (antibody binding site, antibody generation)

References

Showing 2 of 2 references.

Isolation Paper
He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.

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Displaying record number 1070

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MAb ID	35D10/D2
HXB2 Location	gp160(139-155) DNA(6639..6689)	gp160 Epitope Map
Author Location	gp120(gp120 )
Research Contact	Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org
Epitope	NTKSSNWKEMDGEIK	Epitope Alignment
Ab Type	gp120 V1
Neutralizing	L
Species (Isotype)	transgenic mouse(IgG2κ)
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, review, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade SF162
Vaccine component	gp120
Adjuvant	Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 2 of 2 notes.

• 35D10/D2: In an extensive review of gp120 binding MAbs in this database, V1-specific MAbs are noted to be unusual, but in one study transgenic mouse immunization with SF162 yielded ten V1 MAbs with highly strain-specific autologous NAb responses, and V1 was immunodominant. Human MAbs to V1 may be difficult to isolate due to selection with heterologous strains. Gorny2003 (variant cross-reactivity, review)
• 35D10/D2: Transgenic mice (strain XenoMouse G2) carrying human genes allowing production of fully human IgG2kappa MAbs were used to rapidly create a panel of anti-HIV gp120 MAb-producing hybridomas by immunization with HIV SF162 gp120 -- several of the MAbs obtained were effective at neutralizing the autologous strain -- C-term-V1- region was immunodominant in these mice and the ten V1-specific MAbs could potently neutralize autologous strain SF162 but were highly type specific. He2002 (antibody binding site, antibody generation)

References

Showing 2 of 2 references.

Isolation Paper
He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.

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Displaying record number 1071

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MAb ID	40H2/C7
HXB2 Location	gp160(139-155) DNA(6639..6689)	gp160 Epitope Map
Author Location	gp120(gp120 )
Research Contact	Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org
Epitope	NTKSSNWKEMDGEIK	Epitope Alignment
Ab Type	gp120 V1
Neutralizing	L
Species (Isotype)	transgenic mouse(IgG2κ)
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, review, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade SF162
Vaccine component	gp120
Adjuvant	Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 2 of 2 notes.

• 40H2/C7: In an extensive review of gp120 binding MAbs in this database, V1-specific MAbs are noted to be unusual, but in one study transgenic mouse immunization with SF162 yielded ten V1 MAbs with highly strain-specific autologous NAb responses, and V1 was immunodominant. Human MAbs to V1 may be difficult to isolate due to selection with heterologous strains. Gorny2003 (variant cross-reactivity, review)
• 40H2/C7: Transgenic mice (strain XenoMouse G2) carrying human genes allowing production of fully human IgG2kappa MAbs were used to rapidly create a panel of anti-HIV gp120 MAb-producing hybridomas by immunization with HIV SF162 gp120 -- several of the MAbs obtained were effective at neutralizing the autologous strain -- C-term-V1- region was immunodominant in these mice and the ten V1-specific MAbs could potently neutralize autologous strain SF162 but were highly type specific. He2002 (antibody binding site, antibody generation)

References

Showing 2 of 2 references.

Isolation Paper
He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.

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Displaying record number 1072

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MAb ID	43A3/E4
HXB2 Location	gp160(139-155) DNA(6639..6689)	gp160 Epitope Map
Author Location	gp120(gp120 )
Research Contact	Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org
Epitope	NTKSSNWKEMDGEIK	Epitope Alignment
Ab Type	gp120 V1
Neutralizing
Species (Isotype)	transgenic mouse(IgG2κ)
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, review, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade SF162
Vaccine component	gp120
Adjuvant	Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 2 of 2 notes.

• 43A3/E4: In an extensive review of gp120 binding MAbs in this database, V1-specific MAbs are noted to be unusual, but in one study transgenic mouse immunization with SF162 yielded ten V1 MAbs with highly strain-specific autologous NAb responses, and V1 was immunodominant. Human MAbs to V1 may be difficult to isolate due to selection with heterologous strains. Gorny2003 (variant cross-reactivity, review)
• 43A3/E4: Transgenic mice (strain XenoMouse G2) carrying human genes allowing production of fully human IgG2kappa MAbs were used to rapidly create a panel of anti-HIV gp120 MAb-producing hybridomas by immunization with HIV SF162 gp120 -- several of the MAbs obtained were effective at neutralizing the autologous strain -- C-term-V1- region was immunodominant in these mice and the ten V1-specific MAbs could potently neutralize autologous strain SF162 but were highly type specific. He2002 (antibody binding site, antibody generation)

References

Showing 2 of 2 references.

Isolation Paper
He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.

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Displaying record number 1073

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MAb ID	43C7/B9
HXB2 Location	gp160(139-155) DNA(6639..6689)	gp160 Epitope Map
Author Location	gp120(gp120 )
Research Contact	Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org
Epitope	NTKSSNWKEMDGEIK	Epitope Alignment
Ab Type	gp120 V1
Neutralizing	L
Species (Isotype)	transgenic mouse(IgG2κ)
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, review, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade SF162
Vaccine component	gp120
Adjuvant	Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 2 of 2 notes.

• 43C7/B9: In an extensive review of gp120 binding MAbs in this database, V1-specific MAbs are noted to be unusual, but in one study transgenic mouse immunization with SF162 yielded ten V1 MAbs with highly strain-specific autologous NAb responses, and V1 was immunodominant. Human MAbs to V1 may be difficult to isolate due to selection with heterologous strains. Gorny2003 (variant cross-reactivity, review)
• 43C7/B9: Transgenic mice (strain XenoMouse G2) carrying human genes allowing production of fully human IgG2kappa MAbs were used to rapidly create a panel of anti-HIV gp120 MAb-producing hybridomas by immunization with HIV SF162 gp120 -- several of the MAbs obtained were effective at neutralizing the autologous strain -- C-term-V1- region was immunodominant in these mice and the ten V1-specific MAbs could potently neutralize autologous strain SF162 but were highly type specific. He2002 (antibody binding site, antibody generation)

References

Showing 2 of 2 references.

Isolation Paper
He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.

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Displaying record number 1074

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MAb ID	45D1/B7
HXB2 Location	gp160(139-155) DNA(6639..6689)	gp160 Epitope Map
Author Location	gp120(gp120 )
Research Contact	Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org
Epitope	NTKSSNWKEMDGEIK	Epitope Alignment
Ab Type	gp120 V1
Neutralizing	L
Species (Isotype)	transgenic mouse(IgG2κ)
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, review, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade SF162
Vaccine component	gp120
Adjuvant	Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 2 of 2 notes.

• 45D1/B7: In an extensive review of gp120 binding MAbs in this database, V1-specific MAbs are noted to be unusual, but in one study transgenic mouse immunization with SF162 yielded ten V1 MAbs with highly strain-specific autologous NAb responses, and V1 was immunodominant. Human MAbs to V1 may be difficult to isolate due to selection with heterologous strains. Gorny2003 (variant cross-reactivity, review)
• 45D1/B7: Transgenic mice (strain XenoMouse G2) carrying human genes allowing production of fully human IgG2kappa MAbs were used to rapidly create a panel of anti-HIV gp120 MAb-producing hybridomas by immunization with HIV SF162 gp120 -- several of the MAbs obtained were effective at neutralizing the autologous strain -- C-term-V1- region was immunodominant in these mice and the ten V1-specific MAbs could potently neutralize autologous strain SF162 but were highly type specific. He2002 (antibody binding site, antibody generation)

References

Showing 2 of 2 references.

Isolation Paper
He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.

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Displaying record number 1075

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MAb ID	58E1/B3
HXB2 Location	gp160(139-155) DNA(6639..6689)	gp160 Epitope Map
Author Location	gp120(gp120 )
Research Contact	Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org
Epitope	NTKSSNWKEMDGEIK	Epitope Alignment
Ab Type	gp120 V1
Neutralizing	L
Species (Isotype)	transgenic mouse(IgG2κ)
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, review, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade SF162
Vaccine component	gp120
Adjuvant	Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 2 of 2 notes.

• 58E1/B3: In an extensive review of gp120 binding MAbs in this database, V1-specific MAbs are noted to be unusual, but in one study transgenic mouse immunization with SF162 yielded ten V1 MAbs with highly strain-specific autologous NAb responses, and V1 was immunodominant. Human MAbs to V1 may be difficult to isolate due to selection with heterologous strains. Gorny2003 (variant cross-reactivity, review)
• 58E1/B3: Transgenic mice (strain XenoMouse G2) carrying human genes allowing production of fully human IgG2kappa MAbs were used to rapidly create a panel of anti-HIV gp120 MAb-producing hybridomas by immunization with HIV SF162 gp120 -- several of the MAbs obtained were effective at neutralizing the autologous strain -- C-term-V1- region was immunodominant in these mice and the ten V1-specific MAbs could potently neutralize autologous strain SF162 but were highly type specific. He2002 (antibody binding site, antibody generation)

References

Showing 2 of 2 references.

Isolation Paper
He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.

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Displaying record number 1076

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MAb ID	64B9/A6
HXB2 Location	gp160(139-155) DNA(6639..6689)	gp160 Epitope Map
Author Location	gp120(gp120 )
Research Contact	Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org
Epitope	NTKSSNWKEMDGEIK	Epitope Alignment
Ab Type	gp120 V1
Neutralizing	L
Species (Isotype)	transgenic mouse(IgG2κ)
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, review, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade SF162
Vaccine component	gp120
Adjuvant	Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 2 of 2 notes.

• 64B9/A6: In an extensive review of gp120 binding MAbs in this database, V1-specific MAbs are noted to be unusual, but in one study transgenic mouse immunization with SF162 yielded ten V1 MAbs with highly strain-specific autologous NAb responses, and V1 was immunodominant. Human MAbs to V1 may be difficult to isolate due to selection with heterologous strains. Gorny2003 (variant cross-reactivity, review)
• 64B9/A6: Transgenic mice (strain XenoMouse G2) carrying human genes allowing production of fully human IgG2kappa MAbs were used to rapidly create a panel of anti-HIV gp120 MAb-producing hybridomas by immunization with HIV SF162 gp120 -- several of the MAbs obtained were effective at neutralizing the autologous strain -- C-term-V1- region was immunodominant in these mice and the ten V1-specific MAbs could potently neutralize autologous strain SF162 but were highly type specific. He2002 (antibody binding site, antibody generation)

References

Showing 2 of 2 references.

Isolation Paper
He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.

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Displaying record number 1077

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MAb ID	69D2/A1
HXB2 Location	gp160(139-155) DNA(6639..6689)	gp160 Epitope Map
Author Location	gp120(gp120 )
Research Contact	Dr. Abraham Pinter, Public Health Research Institute, Newark, NJ, pinter@phri.org
Epitope	NTKSSNWKEMDGEIK	Epitope Alignment
Ab Type	gp120 V1
Neutralizing	L
Species (Isotype)	transgenic mouse(IgG2κ)
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, review, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade SF162
Vaccine component	gp120
Adjuvant	Ribi adjuvant (MPL+TDM) (RIBI)

Notes

Showing 2 of 2 notes.

• 69D2/A1: In an extensive review of gp120 binding MAbs in this database, V1-specific MAbs are noted to be unusual, but in one study transgenic mouse immunization with SF162 yielded ten V1 MAbs with highly strain-specific autologous NAb responses, and V1 was immunodominant. Human MAbs to V1 may be difficult to isolate due to selection with heterologous strains. Gorny2003 (variant cross-reactivity, review)
• 69D2/A1: Transgenic mice (strain XenoMouse G2) carrying human genes allowing production of fully human IgG2kappa MAbs were used to rapidly create a panel of anti-HIV gp120 MAb-producing hybridomas by immunization with HIV SF162 gp120 -- several of the MAbs obtained were effective at neutralizing the autologous strain -- C-term-V1- region was immunodominant in these mice and the ten V1-specific MAbs could potently neutralize autologous strain SF162 but were highly type specific. He2002 (antibody binding site, antibody generation)

References

Showing 2 of 2 references.

Isolation Paper
He2002 Yuxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan, and Abraham Pinter. Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci. J. Immunol., 169(1):595-605, 1 Jul 2002. PubMed ID: 12077293. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.

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