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Displaying record number 598

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MAb ID	polyclonal
HXB2 Location	gp160(425-436) DNA(7497..7532)	gp160 Epitope Map
Author Location	gp120
Epitope	`NMWQEVGKAMYA`	Epitope Alignment
Ab Type	gp120 CD4BS
Neutralizing	L
Species (Isotype)	mouse(IgA)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	peptide
Vaccine strain	B clade IIIB
Adjuvant	Cholera toxin (CT)

Notes

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Polyclonal secretory IgA antibody raised by mucosal immunization is able to neutralize IIIB, SF2, and MN -- HIV-1 neutralization may be due to the V3, CD4 or HPG30 component of the multicomponent peptide immunogen. Bukawa1995

References

Showing 1 of 1 reference.

Bukawa1995 H. Bukawa, K.-I. Sekigawa, K. Hamajima, J. Fukushima, Y. Yamada, H. Kiyono, and K. Okuda. Neutralization of HIV-1 by Secretory IgA Induced by Oral Immunization with a New Macromolecular Multicomponent Peptide Vaccine Candidate. Nat. Med., 1:681-685, 1995. This paper studies the anti-HIV-1 antibodies raised in response to a multicomponent peptide vaccine, given orally. It consisted of: V3 loop peptides based on sequences from cyclized B consensus sequence; a PND common in Japan; IIIB PND; Thai B strains PND; a CD4 binding site peptide; and a Gag peptide, HPG30. BALB/c mice were immunized. Serum IgA and IgG and fecal IgA were detected. IgA from fecal samples was capable of neutralizing lab strains. PubMed ID: 7585151. Show all entries for this paper.