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HXB2 Location gp160(92-100)
gp160 Epitope Map
Author Location gp120(92-100 IIIB)
Research Contact Patricia Earl and Christopher Broder, NIH
Epitope NFNMWKNDM Epitope Alignment
NFNMWKNDM epitope logo
Ab Type gp120 C1
Species (Isotype) mouse
Immunogen vaccine

Vaccine Details

Vaccine type protein-Ab complex
Vaccine component gp120-Mab complex


Showing 1 of 1 note.


Showing 1 of 1 reference.

Denisova1996 G. Denisova, B. Stern, D. Raviv, J. Zwickel, N. I. Smorodinsky, and J. M. Gershoni. Humoral Immune Response to Immunocomplexed HIV Envelope Glycoprotein 120. AIDS Res. Hum. Retroviruses, 12:901-909, 1996. Mice were injected with the gp120 in different configurations: free, complexed with CD4, and as an immunocomplex bound to a V3 loop MAb (M77) of the protein. Polyclonal sera, as well as monoclonal antibodies produced in each case, were analyzed. The free gp120 and gp120-CD4 complex immunogens stimulated responses were directed mainly toward conformational epitopes, but gp120 immunocomplexed with MAb M77 also produced numerous and varied MAbs directed toward linear epitopes that were presumably inaccessible on the gp120, gp120-CD4 proteins. PubMed ID: 8798975. Show all entries for this paper.

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