Search Antibody Database

Found 1 matching record:

Displaying record number 51

Download this epitope record as JSON.

MAb ID	CB-13/5 (CB-mab-p24/13-15)
HXB2 Location	Gag(153-157) DNA(1246..1260)	Gag Epitope Map
Author Location	p24(152-156)
Epitope	NAWVK	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1κ)
Patient
Immunogen
Keywords	antibody binding site, antibody sequence, immunotherapy

Notes

Showing 5 of 5 notes.

• CB-13/5: Similarity level of the CB-13/5 binding site pentapeptide NAWVK to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 2 times, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008 (antibody binding site, immunotherapy)
• CB-13/5: Epitope described as VHQAISPRTLNAWVK -- binding not affected by bound MAb CB-4/1. Glaser1996 (antibody binding site)
• CB-13/5: Inhibits spread of HIV-1 in cell cultures. Franke1992
• CB-13/5: Called CB-mab-p24/13-15 -- the VDJ H and VJ L regions of CB-mab-p24/13-15 were sequenced. Kuttner1992 (antibody sequence)
• CB-13/5 database comment: It is not clear whether the MAbs CD-13/5 and CB-mab-p24/13-15 are the same, but from the shared references in the primary articles they seem to be.

References

Showing 5 of 5 references.

Grunow1990 R. Grunow, R. Giess, T. Portsman, H. Dopel, K. Hansel, and R. von Baehr. Development and Biological Testing of Human and Murine Antibodies against HIV Antigens. Z. Klin. Med., 45:367-369, 1990. Show all entries for this paper.

Franke1992 L. Franke, R. Grunow, R. Meissner, T. Portsman, and R. von Baehr. Inhibition of HIV-1 Infection In Vitro by Murine Monoclonal Anti-p24 Antibodies. J. Med. Virol., 37:137-142, 1992. PubMed ID: 1629712. Show all entries for this paper.

Kuttner1992 G. Kuttner, E. Giessmann, B. Niemann, K. Winkler, R. Grunow, J. Hinkula, J. Rosen, B. Wahren, and R. von Baehr. Immunoglobulin V Regions and Epitope Mapping of a Murine Monoclonal Antibody against p24 Core Protein of HIV-1. Mol. Immunol., 29:561-564, 1992. The nucleotide sequence of the VDJ$_H$ and VJ$_L$ regions of a murine MAb (CB-mab-p24/13-5) against p24 was obtained. PubMed ID: 1565102. Show all entries for this paper.

Glaser1996 R. W. Glaser and G. Hausdorf. Binding Kinetics of an Antibody against HIV p24 Core Protein Measured with Real-Time Biomolecular Interaction Analysis Suggest a Slow Conformational Change in Antigen p24. J. Immunol. Methods, 189:1-14, 1996. The MAb CD-4/1 and p24 have unusual biphasic kinetics of association. PubMed ID: 8576571. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.