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MAb ID	polyclonal
HXB2 Location	gp160(305-319) DNA(7137..7181)	gp160 Epitope Map
Author Location	gp120(305- LAI)
Epitope	KSIHIGPGRAFYT	Epitope Alignment
Subtype	B
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG, IgM)
Patient
Immunogen	HIV-1 infection
Keywords	antibody binding site, binding affinity, escape, mutation acquisition

Notes

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• Polyclonal sera from six individuals tested for reactivity against a panel of peptides based on autologous sequences provide evidence for immunological escape mutations in the tip of the V3 loop for consensus epitope KSIHIGPGRAFYT. Epitope RSIHIGPGRAFYT is recognized by polyclonal sera and is predominant at 58 months post-seroconversion, between months 58-96 post-seroconversion, the predominant form is RSIytGPGRAFhT, and this variant is not recognized by the sera of patient Individual-C4. For patient Individual-H495, KSIPIGPGRAFYT is recognized with later variants KSIhIGPGRAFYT and KSIPIGPGkAFYT being recognized less and less. Depending on the patient, different positions in the 13 aa. sequence seem critical for recognition by sera - in patient C4, aa. 4H, 6G, 7P, 8G, 9R; in patient H495, 1K, 6G, 7P, 9R; in H594, 6G, 7P, 9R; in patient P704, 7P. Langedijk1995 (antibody binding site, mutation acquisition, escape, binding affinity)

References

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Langedijk1995 J. P. M. Langedijk, G. Zwart, J. Goudsmit, and R. H. Meloen. Fine Specificity of Antibody Recognition May Predict Amino Acid Substitution in the Third Variable Region of gp120 during HIV Type 1 Infection. AIDS Res. Hum. Retroviruses, 11:1153-1162, 1995. To investigate how HIV-1 escapes from recognition, a panel of V3 peptides based on sequences derived from 6 HIV-1 positive individuals was tested for reactivity with autologous sera sampled over time. The V3 region undergoes immune escape through mutation. PubMed ID: 8573370. Show all entries for this paper.