Search Antibody Database

Found 1 matching record:

Displaying record number 213

Download this epitope record as JSON.

MAb ID	MAb 35
HXB2 Location	Pol(979-988) DNA(5019..5048)	Pol Epitope Map
Author Location	Integrase(264-273)
Epitope	`KAKIIRDYGK`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgGκ)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	protein
Vaccine component	Int

Notes

Showing 4 of 4 notes.

MAb 35: Similarity level of the MAb 35 binding site pentapeptide IRDYG to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 0 times, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
MAb 35: Integrase was shown to have intrinsic DNA polymerase activity that can catalyze gap repair -- MAb 35 inhibits this activity. Acel1998
MAb 35: Although MAb 35 does not inhibit HIV-1 IN, Fab 35 inhibits 3'-end processing, strand transfer and disintegration. Barsov1996
MAb 35: There appears to be two different IN Abs with similar names: MAb 35 and 35. Barsov1996

References

Showing 3 of 3 references.

Barsov1996 E. V. Barsov, W. E. Huber, J. Marcotrigiano, P. K. Clark, A. D. Clark, E. Arnold, and S. H. Hughes. Inhibition of Human Immunodeficiency Virus Type 1 Integrase by the Fab Fragment of a Specific Monoclonal Antibody Suggests that Different Multimerization States Are Required for Different Enzymatic Functions. J. Virol., 70:4484-4494, 1996. MAb 35 does not inhibit HIV-1 IN, but Fab 35 inhibits 3'-end processing, strand transfer and disintegration. This appears to be through interfering with multimerization, and suggests that the C-terminal region is important for IN function. PubMed ID: 8676473. Show all entries for this paper.

Acel1998 A. Acel, B. E. Udashkin, M. A. Wainberg, and E. A. Faust. Efficient gap repair catalyzed in vitro by an intrinsic DNA polymerase activity of human immunodeficiency virus type 1 Integrase. J. Virol., 72:2062-71, 1998. Intrinsic polymerase activity that can catalyze gap repair was described for HIV Integrase. This activity was inhibited by the MAb 35, that binds to KAKIIRDYGK at the C-term end of Integrase. PubMed ID: 9499061. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.