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Found 3 matching records:

Displaying record number 401

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MAb ID	F19.48-3
HXB2 Location	gp160(307-319) DNA(7143..7181)	gp160 Epitope Map
Author Location	gp120(312-324 LAI)
Epitope	IRIQRGPGRAFVT	Epitope Alignment
Subtype	B
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing	L
Species (Isotype)	mouse(IgG2aκ)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

Showing 1 of 1 note.

• F19.48-3: Strain specific -- used to raise anti-idiotype antibodies. Boudet1994

References

Showing 1 of 1 reference.

Boudet1994 F. Boudet, J. Theze, and M. Zouali. Anti-Idiotypic Antibodies to the Third Variable Domain of gp120 Induce an Anti-HIV-1 Antibody Response in Mice. Virology, 200:176-188, 1994. PubMed ID: 7510435. Show all entries for this paper.

Displaying record number 402

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MAb ID	F19.26-4
HXB2 Location	gp160(307-319) DNA(7143..7181)	gp160 Epitope Map
Author Location	gp120(312-324 LAI)
Epitope	IRIQRGPGRAFVT	Epitope Alignment
Subtype	B
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing	L
Species (Isotype)	mouse(IgG2aκ)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

Showing 1 of 1 note.

• F19.26-4: Strain specific -- used to raise anti-idiotype antibodies. Boudet1994

References

Showing 1 of 1 reference.

Boudet1994 F. Boudet, J. Theze, and M. Zouali. Anti-Idiotypic Antibodies to the Third Variable Domain of gp120 Induce an Anti-HIV-1 Antibody Response in Mice. Virology, 200:176-188, 1994. PubMed ID: 7510435. Show all entries for this paper.

Displaying record number 403

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MAb ID	F19.57-11
HXB2 Location	gp160(307-319) DNA(7143..7181)	gp160 Epitope Map
Author Location	gp120(312-324 LAI)
Epitope	IRIQRGPGRAFVT	Epitope Alignment
Subtype	B
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing	L (LAI)
Species (Isotype)	mouse(IgG1κ)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

Showing 2 of 2 notes.

• F19.57-11: Anti-anti-idiotypic antibodies (Ab3) were raised in BALBc mice that had greater breadth of reactivity than the original F19.57-11 (Ab3 could also recognize 1282 and SF2, with aa TRK(R or S)IYIGPGRA(WY or FH)T) Boudet1995
• F19.57-11: MAb F19.57-11 is strain specific for LAI -- used to raise anti-idiotype rabbit antibodies (called 57-B Ab2) Boudet1994

References

Showing 3 of 3 references.

Boudet1991 F. Boudet, J. Theze, and M. Zouali. UV-Treated Polystyrene Microtitre Plates for Use in an ELISA to Measure Antibodies against Synthetic Peptides. J. Immunol. Methods, 142:73-82, 1991. PubMed ID: 1717595. Show all entries for this paper.

Boudet1994 F. Boudet, J. Theze, and M. Zouali. Anti-Idiotypic Antibodies to the Third Variable Domain of gp120 Induce an Anti-HIV-1 Antibody Response in Mice. Virology, 200:176-188, 1994. PubMed ID: 7510435. Show all entries for this paper.

Boudet1995 F. Boudet, H. Keller, M. P. Kieny, and J. Theze. Single Peptide and Anti-Idiotype Based Immunizations Can Broaden the Antibody Response against the Variable V3 Domain of HIV-1 in Mice. Mol. Immunol., 32:449-457, 1995. Given the high degree of sequence variability of the V3 loop, the humoral response to this region tends to be type specific. An anti-idiotypic antibody could broaden the anti-V3 antibody polyclonal response in BALB/c mice, relative to the original Ab used to generate the anti-idiotype response. A synthetic peptide derived from the V3 determinant of HIV-1 MN induced an antibody response to multiple HIV-1 strains, but the extent of this cross-reactivity was inversely correlated with the binding affinity to V3 MN peptide. PubMed ID: 7783749. Show all entries for this paper.