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Displaying record number 1929

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MAb ID	V3-13
HXB2 Location	gp160(307-315) DNA(7143..7169)	gp160 Epitope Map
Author Location	gp120 (V3)
Research Contact	National Institute for Biological Standards and Control
Epitope	IRIQRGPGR	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)
Patient
Immunogen
Keywords	co-receptor, dendritic cells, neutralization

Notes

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• V3-13: Transmission of HIV-1 by immature and mature DCs to CD4+ T lymphocytes was significantly higher for CXCR4- than for CCR5-tropic strains. In addition, V3-13 inhibited transmission of CCR5-tropic viruses while transmission of V3-13-neutralized X4 variants increased, indicating that X4 HIV-1 has an advantage over R5 in transmission when neutralized with V3-13. vanMontfort2008 (co-receptor, neutralization, dendritic cells)

References

Showing 1 of 1 reference.

vanMontfort2008 Thijs van Montfort, Adri A. M. Thomas, Georgios Pollakis, and William A. Paxton. Dendritic Cells Preferentially Transfer CXCR4-Using Human Immunodeficiency Virus Type 1 Variants to CD4+ T Lymphocytes in trans. J. Viro.l, 82(16):7886-7896, Aug 2008. PubMed ID: 18524826. Show all entries for this paper.