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Found 3 matching records:

Displaying record number 436

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MAb ID 5025B
HXB2 Location gp160(309-316)
DNA(7152..7172)
gp160 Epitope Map
Author Location gp120(310-316 BH10)
Epitope IQRGPGRA Epitope Alignment
IQRGPGRA epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing  
Species (Isotype) mouse(IgG)
Patient  
Immunogen vaccine
Keywords antibody generation, antibody lineage, binding affinity, novel epitope, optimal epitope

Vaccine Details

Vaccine type peptide
Vaccine strain B clade BH10
Vaccine component Env V3

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Langedijk1991 J. P. M. Langedijk, N. K. T. Back, P. J. Durda, J. Goudsmit, and R. H. Meloen. Neutralizing activity of anti-peptide antibodies against the principal neutralization domain of human immunodeficiency virus type 1. J. Gen. Virol., 72:2519-2526, 1991. MAbs were raised against RIQRGPGRAFVTIGK by immunizing mice. Fine structure of MAb binding sites was mapped using pepscan. Preservation of the $\beta$ turn at the tip of the loop was critical. PubMed ID: 1919529. Show all entries for this paper.


Displaying record number 437

Download this epitope record as JSON.

MAb ID 5023B
HXB2 Location gp160(309-316)
DNA(7149..7172)
gp160 Epitope Map
Author Location gp120(309-316 BH10)
Epitope IQRGPGRA Epitope Alignment
IQRGPGRA epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing  
Species (Isotype) mouse(IgG)
Patient  
Immunogen vaccine
Keywords antibody generation, antibody interactions, binding affinity, novel epitope, optimal epitope

Vaccine Details

Vaccine type peptide
Vaccine strain B clade BH10
Vaccine component Env V3

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Langedijk1991 J. P. M. Langedijk, N. K. T. Back, P. J. Durda, J. Goudsmit, and R. H. Meloen. Neutralizing activity of anti-peptide antibodies against the principal neutralization domain of human immunodeficiency virus type 1. J. Gen. Virol., 72:2519-2526, 1991. MAbs were raised against RIQRGPGRAFVTIGK by immunizing mice. Fine structure of MAb binding sites was mapped using pepscan. Preservation of the $\beta$ turn at the tip of the loop was critical. PubMed ID: 1919529. Show all entries for this paper.


Displaying record number 492

Download this epitope record as JSON.

MAb ID 5021
HXB2 Location gp160(310-316)
DNA(7152..7172)
gp160 Epitope Map
Author Location gp120
Epitope IQRGPGRA Epitope Alignment
IQRGPGRA epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing L
Species (Isotype) mouse(IgG)
Patient  
Immunogen vaccine
Keywords antibody generation, antibody interactions, binding affinity, novel epitope, optimal epitope

Vaccine Details

Vaccine type peptide
Vaccine strain B clade BH10
Vaccine component Env V3

Notes

Showing 2 of 2 notes.

References

Showing 4 of 4 references.

Durda1988 P. J. Durda, B. Leece, A. M. Jenoski, H. Rabin, A. Fisher, R. Gallo, and F. Wong-Staal. Characterization of Murine Monoclonal Antibodies to HIV-1 Induced by Synthetic Peptides. AIDS Res. Hum. Retroviruses, 4:331-342, 1988. PubMed ID: 2848556. Show all entries for this paper.

Durda1990 P. J. Durda, L. Bacheler, P. Clapham, A. M. Jenoski, B. Leece, T. J. Matthews, A. McKnight, R. Pomerantz, M. Rayner, and K. J. Weinhold. HIV-1 Neutralizing Monoclonal Antibodies Induced by a Synthetic Peptide. AIDS Res. Hum. Retroviruses, 6:1115, 1990. PubMed ID: 1702301. Show all entries for this paper.

Langedijk1991 J. P. M. Langedijk, N. K. T. Back, P. J. Durda, J. Goudsmit, and R. H. Meloen. Neutralizing activity of anti-peptide antibodies against the principal neutralization domain of human immunodeficiency virus type 1. J. Gen. Virol., 72:2519-2526, 1991. MAbs were raised against RIQRGPGRAFVTIGK by immunizing mice. Fine structure of MAb binding sites was mapped using pepscan. Preservation of the $\beta$ turn at the tip of the loop was critical. PubMed ID: 1919529. Show all entries for this paper.

Moore1993c J. P. Moore, M. Thali, B. A. Jameson, F. Vignaux, G. K. Lewis, S.-W. Poon, M. S. Fung, P. J. Durda, L. Akerblom, B. Wahren, D. D. Ho, Q. J. Sattentau, and J. Sodroski. Immunochemical Analysis of the gp120 Surface Glycoprotein of Human Immunodeficiency Virus Type 1: Probing the Structure of the C4 and V4 Domains and the Interaction of the C4 Domain with the V3 Loop. J. Virol., 73:4785-4796, 1993. General observations: C4 and V3 MAbs are sensitive to the way the epitopes are presented, and this sensitivity cannot be correlated to peptide binding. Some V3-C4 domain interaction was indicated based on mutation and interference studies. PubMed ID: 7687303. Show all entries for this paper.


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