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Displaying record number 396

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MAb ID polyclonal
HXB2 Location gp160(311-322)
gp160 Epitope Map
Author Location gp120( MN)
Epitope IGPGRAFYTTKN Epitope Alignment
IGPGRAFYTTKN epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing L (MN ALA-1)
Species (Isotype) guinea pig
Immunogen vaccine

Vaccine Details

Vaccine type human rhinovirus 14
Vaccine strain B clade MN
Vaccine component Env V3


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Showing 1 of 1 reference.

Smith1998 A. D. Smith, S. C. Geisler, A. A. Chen, D. A. Resnick, B. M. Roy, P. J. Lewi, E. Arnold, and G. F. Arnold. Human Rhinovirus Type 14: Human Immunodeficiency Virus Type 1 (HIV-1) V3 Loop Chimeras from a Combinatorial Library Induce Potent Neutralizing Antibody Responses against HIV-1. J. Virol., 72:651-659, 1998. The tip of the MN V3 loop, IGPGRAFYTTKN, was inserted into cold-causing human rhinovirus 14 (HRV14) and chimeras were immunoselected using MAbs 447-52-D, 694/98-D, NM-01, and 59.1, for good presentation of the V3 antigenic region. The selected chimeric viruses were neutralized by anti-V3 loop MAbs. The chimeric viruses elicited potent NAbs against ALA-1 and MN in guinea pigs. PubMed ID: 9420270. Show all entries for this paper.

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