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Displaying record number 834

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MAb ID	polyclonal
HXB2 Location	gp160(733-736) DNA(8421..8432)	gp160 Epitope Map
Author Location	gp41(735-752 NL43)
Epitope	IEEE	Epitope Alignment
Ab Type	C-term
Neutralizing	L
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

Showing 1 of 1 note.

• The substitution 725 RG (P[R-->G]GPDRPEGIEEEGGERDRDRS) alters the antigenic exposure of this region on the virion resulting in the loss of the downstream neutralizing epitope ERDRD, increased exposure of the epitope GPDRPEG in the virion, while the epitope IEEE remains unchanged. McLain2001

References

Showing 1 of 1 reference.

McLain2001 L. McLain, J. L. Brown, L. Cheung, S. A. Reading, C. Parry, T. D. Jones, S. M. Cleveland, and N. J. Dimmock. Different effects of a single amino acid substitution on three adjacent epitopes in the gp41 C-terminal tail of a neutralizing antibody escape mutant of human immunodeficiency virus type 1. Arch. Virol., 146(1):157--66, 2001. PubMed ID: 11266210. Show all entries for this paper.

Displaying record number 833

Download this epitope record as JSON.

MAb ID	polyclonal
HXB2 Location	gp160(733-736) DNA(8421..8432)	gp160 Epitope Map
Author Location	gp41(735-752 IIIB)
Epitope	IEEE	Epitope Alignment
Ab Type	C-term
Neutralizing	L
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

Showing 2 of 2 notes.

• The substitution 725 RG (P[R-->G]GPDRPEGIEEEGGERDRDRS) alters the antigenic exposure of this region on the virion resulting in the loss of the downstream neutralizing epitope ERDRD, increased exposure of the epitope GPDRPEG in the virion, while the epitope IEEE remains unchanged. McLain2001
• When PRGPDRPEGIEEEGGERDRDRS was used as antigen an immunodominant, non-neutralizing response to IEEE was observed, but immunization GERDRDR shifts the response to ERDRD. Cleveland2000a

References

Showing 2 of 2 references.

Cleveland2000a S. M. Cleveland, T. D. Jones, and N. J. Dimmock. Properties of a Neutralizing Antibody That Recognizes a Conformational Form of Epitope ERDRD in the gp41 C-Terminal Tail of Human Immunodeficiency Virus Type 1. J. Gen. Virol., 81(5):1251-1260, 2000. PubMed ID: 10769067. Show all entries for this paper.

McLain2001 L. McLain, J. L. Brown, L. Cheung, S. A. Reading, C. Parry, T. D. Jones, S. M. Cleveland, and N. J. Dimmock. Different effects of a single amino acid substitution on three adjacent epitopes in the gp41 C-terminal tail of a neutralizing antibody escape mutant of human immunodeficiency virus type 1. Arch. Virol., 146(1):157--66, 2001. PubMed ID: 11266210. Show all entries for this paper.