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Displaying record number 1170

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MAb ID	TB12
HXB2 Location	Tat(44-60) DNA(5960..6010)	Tat Epitope Map
Author Location	Tat(44-61 Lai/Bru)
Research Contact	Dr. J.-L. Guesdon, Institut Pasteur, Paris
Epitope	`GISYGRKKRRQRRPPQG`	Epitope Alignment
Subtype	B
Ab Type	Tat basic region
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords	subtype comparisons

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade BRU
Vaccine component	Tat
Adjuvant	Complete Freund's Adjuvant (CFA)

Notes

Showing 1 of 1 note.

This is one of 5 anti-Tat murine monoclonal antibodies generated in this study. TB12 is clade B and D specific, and does not recognize Tat from clade A, C, or CRF01 (AE). It reacts strongly with aa 1-61, and is also able to react with aa 44-61, in the basic region involved in Tat uptake. Belliard2003 (subtype comparisons)

References

Showing 1 of 1 reference.

Belliard2003 Guillaume Belliard, Anthony Romieu, Jean François Zagury, Hayet Dali, Olivier Chaloin, Roger Le Grand, Erwann Loret, Jean Paul Briand, Bernard Roques, Claude Desgranges, and Sylviane Muller. Specificity and Effect on Apoptosis of Tat Antibodies from Vaccinated and SHIV-Infected Rhesus Macaques and HIV-Infected Individuals. Vaccine, 21(23):3186-3199, 4 Jul 2003. PubMed ID: 12804847. Show all entries for this paper.