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Displaying record number 566

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MAb ID	H11
HXB2 Location	gp160(472-477) DNA(7638..7655)	gp160 Epitope Map
Author Location	gp120(472-477 HXB2)
Epitope	GGDMRD	Epitope Alignment
Subtype	B
Ab Type	gp120 C5
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen
Keywords

Notes

Showing 1 of 1 note.

• H11: Binds to gp120 but not to infected cells -- when linked to ricin A, the immunotoxin did not mediate cell killing -- sCD4 has no effect. Pincus1993,Pincus1996

References

Showing 2 of 2 reference.

Pincus1993 S. H. Pincus and J. McClure. Soluble CD4 Enhances the Efficacy of Immunotoxins Directed against gp41 of the Human Immunodeficiency Virus. Proc. Natl. Acad. Sci. U.S.A., 90:332-336, 1993. PubMed ID: 8419938. Show all entries for this paper.

Pincus1996 S. H. Pincus, K. Wehrly, R. Cole, H. Fang, G. K. Lewis, J. McClure, A. J. Conley, B. Wahren, M. R. Posner, A. L. Notkins, S. A. Tilley, A. Pinter, L. Eiden, M. Teintze, D. Dorward, and V. V. Tolstikov. In Vitro Effects of Anti-HIV Immunotoxins Directed against Multiple Epitopes on HIV Type 1 Envelope Glycoprotein 160. AIDS Res. Hum. Retroviruses, 12:1041-1051, 1996. A panel of anti-gp160 MAbs to was used to construct anti-HIV immunotoxins by coupling antibodies to ricin A chain (RAC). The ability of the immunotoxins to kill HIV-1-infected cells was tested in tissue culture. Immunotoxins that bind epitopes on the cell surface killed infected cells, although killing was not directly proportional to binding. The activity of anti-gp41 immunotoxins was markedly enhanced in the presence of sCD4. PubMed ID: 8827220. Show all entries for this paper.