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Displaying record number 446

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MAb ID	polyclonal
HXB2 Location	Gag(11-25) DNA(820..864)	Gag Epitope Map
Author Location	p17(11-25 LAI)
Epitope	GELDRWEKIRLRPGG	Epitope Alignment
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

Showing 1 of 1 note.

• An ELISA assay was used to study a panel of Gag peptides -- mature p24 CA epitopes mapped to residues 176-192, 201-218, 233-253, 285-304, and were recognized by antibodies elicited by rp24CA -- one p17MA epitope, residues 11-25, and one p24CA epitope, residues 176-192, were recognized by antibodies raised against anti-p55 virus-like particles, suggesting different antigenic properties for p24CA and p17MA antibodies depending on whether they are produced against the mature soluble protein or the immature assembled form of the gag proteins. Truong1997

References

Showing 1 of 1 reference.

Truong1997 C. Truong, D. Brand, F. Mallet, P. Roingeard, and F. Barin. Comparison of antibody responses to different forms of HIV-1 core antigens by epitope mapping. J. Med. Virol., 51(3):145--51, Mar 1997. PubMed ID: 9139076. Show all entries for this paper.

Displaying record number 2

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MAb ID	L14.17
HXB2 Location	Gag(11-25) DNA(820..864)	Gag Epitope Map
Author Location	p17(11-25 BRU)
Epitope	GELDRWEKIRLRPGG	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

Showing 1 of 1 note.

• L14.17: Similarity level of the L14.17 binding site pentapeptide WEKIR to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 1 time, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008

References

Showing 4 of 4 reference.

Tatsumi1990 M. Tatsumi, C. Devaux, F. Kourilsky, and J. C. Chermann. Characterization of monoclonal antibodies directed against distinct conserved epitopes of human immunodeficiency virus type 1 core proteins. Mol Cell Biochem, 96:127-136, 1990. PubMed ID: 1703272. Show all entries for this paper.

RobertHebmann1992a V. Robert-Hebmann, S. Emiliani, M. Resnicoff, F. Jean, and C. Devaux. Subtyping of human immunodeficiency virus isolates with a panel of monoclonal antibodies: identification of conserved and divergent epitopes on p17 and p25 core proteins. Mol. Immunol., 29:1175-1183, 1992. PubMed ID: 1382219. Show all entries for this paper.

RobertHebmann1992b V. Robert-Hebmann, S. Emiliani, F. Jean, M. Resnicoff, and C. Devaux. Clonal Analysis of Murine B-Cell Response to the Human Immunodeficiency Virus Type 1 (HIV-1)-gag p17 and p25 Antigens. Mol. Immunol., 29:729-738, 1992. PubMed ID: 1376412. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.