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Displaying record number 918

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MAb ID	3D12
HXB2 Location	Nef(31-50) DNA(8887..8946)	Nef Epitope Map
Author Location	Nef(31-50 BRU)
Epitope	GAASRDLEKHGAITSSNTAA	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

Showing 6 of 6 notes.

• 3D12: UK Medical Research Council AIDS reagent: EVA3067.2.
• 3D12: This epitope is similar to a fragment of the human protein vascular endothelial growth factor C, AEPDAGEATAYASKDLE. Maksiutov2002
• 3D12: One of four antibodies used in combination to show HIV Nef protein expressed in astrocytes from 7/14 brain samples from HIV+ individuals -- Nef expression associated with dementia. Ranki1995
• 3D12: Over-expression of Nef in astrocytes from postmortem pediatric CNS tissues. Saito1994
• 3D12: Reacted with Nef from different HIV-1 strains (BRU, IIIB, RF, MN). Ovod1992
• 3D12: Database comment: There is an anti-RT MAb that is also named 3D12.

References

Showing 4 of 4 references.

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.

Ovod1992 V. Ovod, A. Lagerstedt, A. Ranki, F. O. Gombert, R. Spohn, M. Tahtinen, G. Jung, and K. J. Krohn. Immunological Variation and Immunohistochemical Localization of HIV-1 Nef Demonstrated with Monoclonal Antibodies. AIDS, 6:25-34, 1992. Ten anti-Nef MAbs were generated and mapped. Nef is expressed in two isomorphic forms, and was shown to be expressed mainly in the Golgi complex and at the nuclear membrane, but occasionally x in the nucleus, particularly in MT-4 cells. PubMed ID: 1371924. Show all entries for this paper.

Ranki1995 A. Ranki, M. Nyberg, V. Ovod, M. Haltia, I. Elovaara, R. Raininko, H. Haapasalo, and K. Krohn. Abundant Expression of HIV Nef and Rev Proteins in Brain Astrocytes In Vivo Is Associated with Dementia. AIDS, 9:1001-1008, 1995. HIV Nef protein was found in the brain cells of infected individuals with clinical neurological disease. PubMed ID: 8527071. Show all entries for this paper.

Saito1994 Y. Saito, L. Sharer, L. Epstein, and et. al. Overexpression of Nef as a Marker for Restricted HIV-1 Infection of Astrocytes in Postmortem Pediatric Central Nervous Tissues. Neurology, 44:474-481, 1994. PubMed ID: 8145918. Show all entries for this paper.