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Displaying record number 261

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MAb ID	133/11
HXB2 Location	gp160(64-78) DNA(6414..6458)	gp160 Epitope Map
Author Location	gp120(64-78)
Epitope	`EVHNVWATHACVPTD`	Epitope Alignment
Ab Type	gp120 C1
Neutralizing	L
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade IIIB
Vaccine component	gp120

Notes

Showing 2 of 2 notes.

133/11: Similarity level of the 133/11 binding site pentapeptide WATHA to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 0 times, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
133/11: Region of overlap for reactive peptides is WATHA -- weak neutralization of lab strains. Niedrig1992

References

Showing 2 of 2 references.

Niedrig1992 M. Niedrig, H.-P. Harthus, M. Broker, H. Bickhard, G. Pauli, H. R. Gelderblom, and B. Wahren. Inhibition of viral replication by monoclonal antibodies directed against human immunodeficiency virus gp120. J. Gen. Virol., 73:2451-2455, 1992. PubMed ID: 1383412. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.