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Displaying record number 232

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MAb ID	1.2
HXB2 Location	Tat(2-17) DNA(5834..5881)	Tat Epitope Map
Author Location	Tat(1-16)
Epitope	EPVDPRLEWKHPGSQ	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen
Keywords

Notes

Showing 1 of 1 note.

• 1.2: Weak expression of Tat observed in HIV+ brain tissue sample, in contrast to Nef. Ranki1995

References

Showing 2 of 2 reference.

Ovod1992 V. Ovod, A. Lagerstedt, A. Ranki, F. O. Gombert, R. Spohn, M. Tahtinen, G. Jung, and K. J. Krohn. Immunological Variation and Immunohistochemical Localization of HIV-1 Nef Demonstrated with Monoclonal Antibodies. AIDS, 6:25-34, 1992. Ten anti-Nef MAbs were generated and mapped. Nef is expressed in two isomorphic forms, and was shown to be expressed mainly in the Golgi complex and at the nuclear membrane, but occasionally x in the nucleus, particularly in MT-4 cells. PubMed ID: 1371924. Show all entries for this paper.

Ranki1995 A. Ranki, M. Nyberg, V. Ovod, M. Haltia, I. Elovaara, R. Raininko, H. Haapasalo, and K. Krohn. Abundant Expression of HIV Nef and Rev Proteins in Brain Astrocytes In Vivo Is Associated with Dementia. AIDS, 9:1001-1008, 1995. HIV Nef protein was found in the brain cells of infected individuals with clinical neurological disease. PubMed ID: 8527071. Show all entries for this paper.