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Displaying record number 1033

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MAb ID	polyclonal
HXB2 Location	Nef(186-206) DNA(9352..9414)	Nef Epitope Map
Author Location	Nef(185-205 LAI, BRU)
Epitope	`DSRLAFHHVARELHPEYFKNC`	Epitope Alignment
Epitope Name	PF63
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	HIV-1 infection, vaccine
Keywords

Vaccine Details

Vaccine type	protein, PLG microparticle
Vaccine strain	B clade BRU, B clade LAI
Vaccine component	Nef
Adjuvant	Complete Freund's Adjuvant (CFA), PLG

Notes

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Nef encapsulated in poly(DL-lactide-co-glycolide) (PLG) had a more prolonged Ab response than Nef in PBS or in Freund's adjuvant (CFA), still strong after 7 months -- the response was predominantly IgG1, a Th2 immune response -- three linear epitopes, Nef 32-64, 118-167, and 185-205, were frequently recognized by the sera of mice immunized with NefPLG or Nef-CFA, but not after immunization with Nef in PBS, which seemed to preferentially stimulate an Ab response to conformational epitopes. Moureau2002

References

Showing 1 of 1 reference.

Moureau2002 Corinne Moureau, Pierre-Louis Vidal, Yamina Bennasser, Marinette Moynier, Yvan Nicaise, Muriel Aussillous, Sophie Barthelemy, Luc Montagnier, and Elmostafa Bahraoui. Characterization of Humoral and Cellular Immune Responses in Mice Induced by Immunization with HIV-1 Nef Regulatory Protein Encapsulated In Poly(DL-Lactide-Co-Glycolide) Microparticles. Mol. Immunol., 38(8):607-618, Jan 2002. PubMed ID: 11792429. Show all entries for this paper.